Effect of Schizotypy on Cognitive Performance and Its Tuning by COMT val158 Met Genotype Variations in a Large Population of Young Men
Abstract
Background Mirroring schizophrenia, specific dimensions of schizotypy are related to cognitive dysfunction. The relation of schizotypy and state psychopathology to cognitive performance and its link to catechol-O-methyltransferase (COMT) val(158) met genotype variations was studied in a large sample of young men. Methods State psychopathology and schizotypy were assessed with self-rated questionnaires. Cognitive performance was assessed with tests of reasoning ability, sustained attention, and verbal and spatial working memory. Subjects were genotyped for the val(158) met polymorphism of the gene for COMT (low enzymatic activity met/met, intermediate met/val, and high val/val). Results The val/val group had higher scores in measures of state psychopathology as well as negative and disorganized schizotypy dimensions, whereas there was no effect of COMT genotype on cognitive performance measures. Structural equation modeling showed that cognitive performance accuracy but not speed decreased with increasing negative schizotypy, increased with increasing paranoid schizotypy, and was not affected by state psychopathology. Increasing val loading resulted in a dose-dependent increase in the factor loading for the relation between negative schizotypy and cognitive performance accuracy. Conclusions Different schizotypal phenotypes had opposing relations to cognitive performance in the population. COMT genotype modulated the relation between the negative schizotypal phenotype and cogni…
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Schizotypy scores in healthy subjects vary based on differences in dopamine metabolising (COMT) enzymes.
“studies showed that schizotypy scores in healthy subjects vary based on the difference in dopamine metabolising (COMT) enzymes (Smyrnis et al., 2007; Stefanis et al., 2004)”
From Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits (2023) · cites this paper as Smyrnis et al., 2007
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Barnett, J. H., Scoriels, L., & Munafò, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.005 · Cited by 412 · see citing works
The role of schizotypy in the study of the etiology of schizophrenia Spectrum disorders
Barrantes-Vidal, N., Grant, P., & Kwapil, T. R. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu191 · Cited by 329 · see citing works
Linking unfounded beliefs to genetic dopamine availability
Schmack, K., Rössler, H., Sekutowicz, M., Brandl, E. J., Müller, D. J., Petrovic, P., & Sterzer, P. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00521 · Cited by 24 · see citing works
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- Authors
- Smyrnis, N., Avramopoulos, D., Evdokimidis, I., Stefanis, C. N., Tsekou, H., & Stefanis, N. C.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- University Mental Health Research Institute (GR)
- Corresponding author
- Smyrnis, Nikolaos
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 61
- Issue
- 7
- Pages
- 845-853
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2007532520
- Cited by
- 72
- References
- 2
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 5 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 3 · 2012: 10
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizotypy, cognitive performance, COMT Val158Met polymorphism, catechol-O-methyltransferase, negative schizotypy, disorganized schizotypy, working memory, sustained attention, reasoning skills, young men, gene-environment interaction
- MeSH terms
- Adolescent, Adult, Attention, Catechol O-Methyltransferase, Cognition, Genotype, Humans, Male, Methionine, Neuropsychological Tests, Personality Tests, Polymorphism, Genetic, Psychometrics, Psychomotor Performance, Surveys and Questionnaires, Schizotypal Personality Disorder, Valine
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