The FKBP5-Gene in Depression and Treatment Response—an Association Study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort

Lekman, Magnus; Laje, Gonzalo; Charney, Dennis; Rush, A. John; Wilson, Alexander F.; Sorant, Alexa J.M.; Lipsky, Robert; Wisniewski, Stephen R.; Manji, Husseini; McMahon, Francis J.; Paddock, Silvia

doi:10.1016/j.biopsych.2007.10.026

The FKBP5-Gene in Depression and Treatment Response—an Association Study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort

BACKGROUND In a recent study of several antidepressant drugs in hospitalized, non-Hispanic White patients, Binder et al. reported association of markers located within the FKBP5 gene with treatment response after 2 and 5 weeks. Individuals homozygous for the TT-genotype at one of the markers (rs1…