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Cited by 207Attention Deficit Hyperactivity DisorderNeural and Behavioral Psychology StudiesAutism Spectrum Disorder Research

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Misinterpreting Emotional Expressions in Attention-Deficit/Hyperactivity Disorder: Evidence for a Neural Marker and Stimulant Effects

Williams, Leanne M., Hermens, Daniel F., Palmer, Donna, Kohn, Michael, Clarke, Simon, Keage, Hannah, Clark, C. Richard, Gordon, Evian·2008·Biological Psychiatry
DOI 10.1016/j.biopsych.2007.11.022
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Abstract

Background In addition to cognitive impairment, there are disruptions to mood and emotion processing in attention-deficit/hyperactivity disorder (ADHD) but little is known about their neural basis. We examined ADHD disturbances in mood and emotion recognition and underlying neural systems before and after treatment with stimulant medication.Methods Participants were 51 unmedicated ADHD adolescents and 51 matched healthy control subjects rated for depressed and anxious mood and accuracy for identifying facial expressions of basic emotion. Brain function was recorded using event-related potentials (ERPs) while subjects viewed these expressions. ADHD subjects were retested after 4 weeks, following treatment with methylphenidate (MPH).Results ADHD subjects showed a profile of emotion-related impairment: higher depression and anxiety, deficits in identifying threat-related emotional expressions in particular, and alterations in ERPs. There was a pronounced reduction in occipital activity during the early perceptual analysis of emotional expression (within 120 msec), followed by an exaggeration of activity associated with structural encoding (120-220 msec) and subsequent reduction and slowing of temporal brain activity subserving context processing (300-400 msec). Methylphenidate normalized neural activity and produced some improvement of emotion recognition but had no impact on negative mood. Improvements in neural activity with MPH were consistent predictors of improvement in clinical features of emotional lability and hyperactivity.Conclusions Objective behavioral and brain function measures of emotion processing may provide a valuable addition to the clinical armamentarium for assessing emotional disturbances in ADHD and the efficacy of stimulants for treating these disturbances.

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Authors
Williams, L. M., Hermens, D. F., Palmer, D., Kohn, M., Clarke, S., Keage, H., Clark, C. R., & Gordon, E.
Affiliations
  • The University of Sydney (AU)
  • Flinders University (AU)
Corresponding author
Williams, Leanne M.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2008-05
Volume
63
Issue
10
Pages
917-926
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2007.11.022
OpenAlex
W2125473615
Cited by
207
References
53
Citations by year
2026: 2 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 18 · 2019: 15 · 2018: 15 · 2017: 18 · 2016: 11 · 2015: 15 · 2014: 20 · 2013: 15 · 2012: 13
FWCI
8.18
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
  • Flinders Academic Commons (Flinders University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords
attention deficit hyperactivity disorder, emotion recognition, facial expression perception, methylphenidate, stimulant medication, depression, anxiety, event-related potentials, neural markers, adolescents, emotional lability, hyperactivity
MeSH terms
Adolescent, Central Nervous System Stimulants, Anxiety, Attention Deficit Disorder with Hyperactivity, Brain Mapping, Child, Depression, Electroencephalography, Emotions, Evoked Potentials, Visual, Facial Expression, Female, Humans, Male, Methylphenidate, Pattern Recognition, Visual, Photic Stimulation, Case-Control Studies

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