Prefrontal cortical gamma-aminobutyric acid levels in panic disorder determined by proton magnetic resonance spectroscopy
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Background Panic disorder (PD) is hypothesized to be associated with altered function of the major inhibitory neurotransmitter, gamma-aminobutyric acid (GABA). Previous proton magnetic resonance spectroscopy (MRS) studies found lower GABA concentrations in the occipital cortex of subjects with PD relative to healthy control subjects. The current study is the first MRS study to compare GABA concentrations between unmedicated PD subjects and control subjects in the prefrontal cortex (PFC).Methods Unmedicated subjects with PD (n = 17) and age- and sex-matched healthy control subjects (n = 17) were scanned on a 3 Tesla scanner using a transmit-receive head coil that provided a sufficiently homogenous radiofrequency field to obtain spectroscopic measurements in the dorsomedial/dorsal anterolateral and ventromedial areas of the PFC.Results The prefrontal cortical GABA concentrations did not differ significantly between PD subjects and control subjects. There also was no statistically significant difference in glutamate/glutamine (Glx), choline, or N-acetyl aspartate concentrations.Conclusions The previously reported finding of reduced GABA concentrations in the occipital cortex of PD subjects does not appear to extend to the PFC.
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Alterations in central GABA receptor expression are implicated in the pathogenesis of anxiety and depression.
“This is not surprising, since alterations in central GABA receptor expression are implicated in the pathogenesis of anxiety and depression (130, 131).”
From Vagus Nerve as Modulator of the Brain–Gut Axis in Psychiatric and Inflammatory Disorders (2018) · cites this paper as [131]
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References 23 · Cited by 58
- Authors
- Hasler, G., van der Veen, J. W., Geraci, M., Shen, J., Pine, D., & Drevets, W. C.
- Affiliations
- University Hospital Zurich (CH)
- National Institutes of Health (US)
- Corresponding author
- Hasler, Gregor
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 65
- Issue
- 3
- Pages
- 273-275
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2660669
- OpenAlex
- W1995537226
- Cited by
- 58
- References
- 23
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 9
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- PubMed Central (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Institutes of Health (Z99 MH999999)
- National Institute of Mental Health (Z01MH002789, Z01MH002803, Z01MH002894)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- panic disorder, GABA, prefrontal cortex, 1H NMR, GABA levels, glutamate/glutamine, choline, N-acetylaspartate, inhibitory neurotransmitter, occipital cortex, unmedicated patients
- MeSH terms
- Adolescent, Adult, Aspartic Acid, Brain Chemistry, Choline, Female, gamma-Aminobutyric Acid, Humans, Male, Middle Aged, Magnetic Resonance Spectroscopy, Occipital Lobe, Psychiatric Status Rating Scales, Panic Disorder, Prefrontal Cortex, Young Adult
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