Associations Between Self-Reported and Objectively Recorded Early Life Stress, FKBP5 Polymorphisms, and Depressive Symptoms in Midlife

Lahti, Jari; Ala-Mikkula, Heidi; Kajantie, Eero; Haljas, Kadri; Eriksson, Johan G.; Räikkönen, Katri

doi:10.1016/j.biopsych.2015.10.022

Associations Between Self-Reported and Objectively Recorded Early Life Stress, FKBP5 Polymorphisms, and Depressive Symptoms in Midlife

BACKGROUND FK506-binding protein 51 is involved in hypothalamic-pituitary-adrenal axis regulation. Single nucleotide polymorphisms (SNPs) in the FKBP5 gene have been shown to interact with retrospectively self-reported early life stress (ELS) in patients with psychiatric disorders. We examined in…