Combined Analysis of Mifepristone for Psychotic Depression: Plasma Levels Associated With Clinical Response

Block, Thaddeus S.; Kushner, Harvey; Kalin, Ned; Nelson, Craig; Belanoff, Joseph; Schatzberg, Alan

doi:10.1016/j.biopsych.2018.01.008

Combined Analysis of Mifepristone for Psychotic Depression: Plasma Levels Associated With Clinical Response

BACKGROUND Patients with psychotic depression exhibit elevated cortisol levels. Competitively antagonizing cortisol at the glucocorticoid receptor with mifepristone demonstrated therapeutic benefit in early studies of patients with psychotic depression. We present a combined analysis of all contr…