Histone Crotonylation Makes Its Mark in Depression Research
Open accessThe claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several uncommon histone modifications, such as histone crotonylation, histone phosphorylation, and histone β-hydroxybutyrylation, are involved in the pathophysiology of MDD.
“Several uncommon histone modifications, such as histone crotonylation, histone phosphorylation, and histone β-hydroxybutyrylation, are shown to be involved in the pathophysiology of MDD.176–178”
From Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential (2023) · cites this paper as [176]
The main text (page unavailable) reports altered histone crotonylation in stress-susceptible mice and describes a possible role in depressive-like behavior. It also says the evidence for crotonylation remains correlational. Thus, it supports a link to a model of depression, but not the unqualified claim that crotonylation is shown to be involved in MDD pathophysiology; it does not establish the other two modifications. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 10 · Cited by 10
Research works printed but not linked: 9
- [1]Sun H, Kennedy PJ, Nestler EJ (2013): Epigenetics of the depressed brain: Role of histone acetylation and methylation. Neuropsychopharmacology 38: 124137. PMC3521990 22692567
- [3]Tan M, Luo H, Lee S, Jin F, Yang JS, Montellier E, (2011): Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell 146: 1016– 1028. 21925322 PMC3176443
- [4]Sabari BR, Zhang D, Allis CD, Zhao Y (2017): Metabolic regulation of gene expression through histone acylations. Nat Rev Mol Cell Biol 18: 90– 101. 27924077 PMC5320945
- [5]Fellows R, Denizot J, Stellato C, Cuomo A, Jain P, Stoyanova E, (2018): Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases. Nat Commun 9: 105. 29317660 PMC5760624
- [6]Sabari BR, Tang Z, Huang H, Yong-Gonzalez V, Molina H, Kong HE, (2015): Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation. Mol Cell 58: 203– 215. 25818647 PMC4501262
- [7]Li Y, Sabari BR, Panchenko T, Wen H, Zhao D, Guan H, (2016): Molecular coupling of histone crotonylation and active transcription by AF9 YEATS domain. Mol Cell 62: 181– 193. 27105114 PMC4841940
- [8]Simithy J, Sidoli S, Yuan ZF, Coradin M, Bhanu NV, Marchione DM, (2017): Characterization of histone acylations links chromatin modifications with metabolism. Nat Commun 8: 1141. 29070843 PMC5656686
- [9]Liu S, Yu H, Liu Y, Liu X, Zhang Y, Bu C, (2017): Chromodomain protein CDYL acts as a crotonyl-CoA hydratase to regulate histone crotonylation and spermatogenesis. Mol Cell 67: 853– 866. 28803779
- [10]Neto FL, Borges G, Torres-Sanchez S, Mico JA, Berrocoso E (2011): Neurotrophins role in depression neurobiology: A review of basic and clinical evidence. Curr Neuropharmacol 9: 530– 552. 22654714 PMC3263450
- Authors
- Chan, J. C., & Maze, I.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Maze, Ian
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 85
- Issue
- 8
- Pages
- 616-618
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC6905464
- OpenAlex
- W2965928181
- Cited by
- 10
- References
- 10
- Citations by year
- 2026: 2 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 2
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (P50 MH096890, DP1 DA042078, R21DA044767)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- histone crotonylation, CDYL, major depressive disorder, stress-induced depression, epigenetic regulation, histone modifications, chromatin regulation, traumatic events
- MeSH terms
- Depression, Depressive Disorder, Histones, Humans, Protein Processing, Post-Translational
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
