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Cited by 430

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Traumatic Brain Injury and Risk of Neurodegenerative Disorder

Open access
Brett, Benjamin L., Gardner, Raquel C., Godbout, Jonathan, Dams-O’Connor, Kristen, Keene, C. Dirk·2022·Biological Psychiatry
DOI 10.1016/j.biopsych.2021.05.025
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Abstract

Traumatic brain injury (TBI), particularly of greater severity (i.e., moderate-to-severe), has been identified as a risk factor for all-cause dementia and Parkinson’s disease (PD), with risk for specific dementia sub-types being more variable. Among the limited studies involving neuropathological (post-mortem) confirmation, the association between TBI and risk for neurodegenerative disease increases in complexity, with polypathology often reported on examination. The heterogeneous clinical and neuropathological outcomes associated with TBI are likely reflective of the multifaceted post-injury acute and chronic processes that may contribute to neurodegeneration. Acutely in TBI, axonal injury and disrupted transport influences molecular mechanisms fundamental to the formation of pathological proteins, such as amyloid (A) β peptide and hyperphosphorylated tau (pTau). These protein deposits may develop into Aβ plaques, pTau positive neurofibrillary tangles and dystrophic neurites. These and other characteristic neurodegenerative diseases pathologies may then spread across brain regions. The acute immune and neuroinflammatory response involves alteration of microglia, astrocytes, oligodendrocytes, and endothelial cells, release of downstream pro- and anti-inflammatory cytokines and chemokines, and recruitment of peripheral immune cells. Though thought to be neuroprotective and reparative initially, prolongation of these processes may promote neurodegeneration. We review the evidence for TBI as a risk factor for neurodegenerative disorders, including Alzheimer’s dementia and PD, in clinical and neuropathological studies. Further, we describe the dynamic interactions between acute response to injury and chronic processes that may be involved in TBI-related pathogenesis and progression of neurodegeneration.

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Metadata

Authors
Brett, B. L., Gardner, R. C., Godbout, J., Dams-O’Connor, K., & Keene, C. D.
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2022-03
Volume
91
Issue
5
Pages
498-507
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2021.05.025
OpenAlex
W3170885926
Cited by
430
References
50
FWCI
31.86
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Traumatic Brain Injury and Risk of Neurodegenerative Disorder. https://app.cochat.ai/papers/10.1016/j.biopsych.2021.05.025
The paper
Brett, B. L., Gardner, R. C., Godbout, J., Dams-O’Connor, K., & Keene, C. D. (2022). Traumatic Brain Injury and Risk of Neurodegenerative Disorder. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2021.05.025

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.