Influence of SLC6A3 and COMT variation on neural activation during response inhibition
Open accessAbstract
There is evidence concerning the neural and genetic correlates of inhibitory control, but there have been limited attempts to combine this information. This study tested the hypothesis that two dopaminergic polymorphisms, SLC6A3 and COMT, influence neural activation during response inhibition. Healthy adults were genotyped for these polymorphisms and performed a measure of response inhibition while undergoing functional magnetic resonance imaging (fMRI). Results support the role of key frontostriatal regions underlying response inhibition. Furthermore, results support a significant influence of SLC6A3 and COMT variants on neural activity during inhibition, with greater activation during inhibition in carriers of the SLC6A3 9-allele or the COMT met-allele as compared to carriers of the SLC6A3 10/10 genotype or the COMT val/val genotype. These results add to a growing literature suggesting that inhibitory control is sensitive to variation in dopamine function, and suggest that this variation may be detectable at the level of individuals' genotypes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A COMT polymorphism with decreased function is associated with increased activation of the IFG during action cancelation and decreased interference inhibition, although conflicting results have also been reported.
“A polymorphism of COMT with decreased function (Chen et al., 2004), was associated with increased activation of the IFG during action cancelation (Congdon et al., 2009) and decreased interference inhibition (Solis-Ortiz et al., 2010), although conflicting results have also been reported (Kramer et al., 2007).”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Congdon et al., 2009
Genetic polymorphisms that increase expression of the DaT are associated with impaired performance on an interference control task and decreased brain activation in the STN and pre-SMA during action cancelation.
“Genetic polymorphisms that increased expression of the DaT have been associated with impaired performance on an interference control task (Cornish et al., 2005) and decreased brain activation in the STN and pre-SMA during action cancelation (Congdon et al., 2009).”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Congdon et al., 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 95 · Cited by 103
- Authors
- Congdon, E., Constable, R. T., Lesch, K. P., & Canli, T.
- Affiliations
- University of California, Los Angeles (US)
- Yale University (US)
- University of Würzburg (DE)
- Stony Brook University (US)
- Corresponding author
- Congdon, Eliza
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 81
- Issue
- 3
- Pages
- 144-152
- ISSN
- 0301-0511 (ISSN-L)
- PMC
- PMC2689843
- OpenAlex
- W2126386765
- Cited by
- 103
- References
- 95
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 6 · 2015: 16 · 2014: 13 · 2013: 9 · 2012: 10
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation
- Yale University
- Deutsche Forschungsgemeinschaft
- Stony Brook University
- National Institutes of Health
- National Institute of Mental Health (F31MH079643)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- dopamine transporter, catechol-O-methyltransferase, response inhibition, inhibitory control, genetic polymorphism, neural correlates of inhibition, dopaminergic activity
- MeSH terms
- Adolescent, Adult, Brain, Brain Mapping, Catechol O-Methyltransferase, Female, Gene Frequency, Genotype, Humans, Image Processing, Computer-Assisted, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Neural Inhibition, Neuropsychological Tests, Oxygen, Polymorphism, Genetic, Dopamine Plasma Membrane Transport Proteins, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
