Amygdala–cingulate intrinsic connectivity is associated with degree of social inhibition
Open accessAbstract
The tendency to approach or avoid novel people is a fundamental human behavior and is a core dimension of social anxiety. Resting state fMRI was used to test for an association between social inhibition and intrinsic connectivity in 40 young adults ranging from low to high in social inhibition. Higher levels of social inhibition were associated with specific patterns of reduced amygdala-cingulate cortex connectivity. Connectivity was reduced between the superficial amygdala and the rostral cingulate cortex and between the centromedial amygdala and the dorsal anterior cingulate cortex. Social inhibition also modulated connectivity in several well-established intrinsic networks; higher social inhibition correlated with reduced connectivity with default mode and dorsal attention networks and enhanced connectivity in salience and executive control networks. These findings provide important preliminary evidence that social inhibition reflects differences in the underlying intrinsic connectivity of the brain in the absence of social stimuli or stressors.
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Higher levels of social inhibition are associated with reduced connectivity between the left amygdala and the insula, dACC, and hippocampus.
“Moreover, higher levels of social inhibition, defined as the tendency to withdrawal from people or avoid social situations, is associated with reduced connectivity between the left amygdala and the insula, dACC, and hippocampus (Blackford et al, 2014).”
From Oxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder (2015) · cites this paper as Blackford et al, 2014
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References 129 · Cited by 67
Research works printed but not linked: 1
- First MB Spitzer RL Gibbon M Williams JBW 2002 Structured clinical interview For DSM-IV-TR Axis I disorders, research version, patient edition (SCID-I/P) New York Biometrics Research, New York State Psychiatric Institute
- Authors
- Blackford, J. U., Clauss, J. A., Avery, S. N., Cowan, R. L., Benningfield, M. M., & VanDerKlok, R. M.
- Affiliations
- Vanderbilt University (US)
- Corresponding author
- Blackford, Jennifer Urbano
- ORCID
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 99
- Pages
- 15-25
- ISSN
- 0301-0511 (ISSN-L)
- PMC
- PMC4274047
- OpenAlex
- W2043945427
- Cited by
- 67
- References
- 129
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 7 · 2017: 6 · 2016: 8 · 2015: 9 · 2014: 4
- FWCI
- 5.02
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (TL1TR000447, UL1TR000445)
- National Institute of Mental Health (R21MH073800, F31MH102008, T32MH018921, MH018921, K01MH083052, MH083052, MH102008, MH073800, MH097344, F30MH097344)
- National Institute on Drug Abuse (DA015137, R01DA015137, DA020149, R21DA020149, DA000357, K12DA000357)
- National Institute of General Medical Sciences (GM 07347, T32GM007347)
- National Center for Research Resources (RR024978, RR024975, TL1RR024978, UL1RR024975)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- social inhibition, amygdala, cingulate cortex, intrinsic functional connectivity, resting-state functional connectivity, social anxiety, default mode network, dorsal attention network, salience network, frontoparietal network, superficial amygdala, centromedial amygdala, dorsal anterior cingulate cortex
- MeSH terms
- Adolescent, Adult, Amygdala, Anxiety Disorders, Female, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Inhibition, Psychological, Functional Laterality, Magnetic Resonance Imaging, Male, Neural Pathways, Oxygen, Social Behavior, Young Adult, Self Report
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