The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Biofunctionalized two-dimensional Ti3C2 MXenes for ultrasensitive detection of cancer biomarker
Open accessAbstract
In this work, ultrathin Ti3C2-MXene nanosheets were synthesized by minimally intensive layer delamination methods, and uniformly functionalized with aminosilane (f-Ti3C2-MXene) to provide a covalent binding for the immobilized bio-receptor (anti-CEA) for label free, ultrasensitive detection of cancer biomarker (carcinoembryonic antigen, CEA). The effect of different redox probes on the electrochemical behavior of f-Ti3C2-MXene was investigated and found that hexaammineruthenium ([Ru(NH3)6]3+) is the preferable redox probe for biosensing. The fabricated biofunctionalized Ti3C2-MXene exhibits a linear detection range of 0.0001-2000 ng mL-1 with sensitivity of 37.9 µA ng-1 mL cm-2 per decade. The wider linear detection range of our f-Ti3C2-MXene is not only higher than previously reported pristine 2D nanomaterials, but is even comparable to other hybrid 2D nanomaterials. We believe that this work opens a new window for development of MXene-based highly sensitive DNA, aptamer, enzyme, antibody, and cell based biosensors, and could be further used in drug delivery application.
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Cites
Metallic Ti3C2T x MXene Gas Sensors with Ultrahigh Signal-to-Noise Ratio
Kim, S. J., Koh, H.-J., Ren, C. E., Kwon, O., Maleski, K., Cho, S.-Y., Anasori, B., Kim, C.-K., Choi, Y.-K., Kim, J., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b07460 · Cited by 1,699
Cited by
A Review on MXene Synthesis, Stability, and Photocatalytic Applications
Murali, G., Reddy Modigunta, J. K., Park, Y. H., Lee, J.-H., Rawal, J., Lee, S.-Y., In, I., & Park, S.-J. (2022) · ACS Nano · doi:10.1021/acsnano.2c04750 · Cited by 668
Recent progress and advances in the environmental applications of MXene related materials
Chen, J., Huang, Q., Huang, H., Mao, L., Liu, M., Zhang, X., & Wei, Y. (2020) · Nanoscale · doi:10.1039/c9nr08542d · Cited by 298
Surface Terminations of MXene: Synthesis, Characterization, and Properties
Tang, M., Li, J., Wang, Y., Han, W., Xu, S., Lu, M., Zhang, W., & Li, H. (2022) · Symmetry · doi:10.3390/sym14112232 · Cited by 279
Ti3C2 2D MXene: Recent Progress and Perspectives in Photocatalysis
Tang, R., Xiong, S., Gong, D., Deng, Y., Wang, Y., Su, L., Ding, C., Yang, L., & Liao, C. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c12905 · Cited by 259
Zhao, F., Yao, Y., Jiang, C., Shao, Y., Barceló, D., Ying, Y., & Ping, J. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2019.121358 · Cited by 253
Metadata
- Authors
- Kumar, S., Lei, Y., Alshareef, N. H., Quevedo-Lopez, M. A., & Salama, K. N.
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 121
- Pages
- 243-249
- ISSN
- 0956-5663 (ISSN-L)
- OpenAlex
- W2889373623
- Cited by
- 463
- References
- 1
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- green
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- Kumar, S., Lei, Y., Alshareef, N. H., Quevedo-Lopez, M. A., & Salama, K. N. (2018). Biofunctionalized two-dimensional Ti3C2 MXenes for ultrasensitive detection of cancer biomarker. Biosensors and Bioelectronics. https://doi.org/10.1016/j.bios.2018.08.076
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