Exosome biogenesis, bioactivities and functions as new delivery systems of natural compounds
Abstract
A rapidly growing body of experimental evidence has begun to shed light on the wide ranging molecular mechanisms which modulate intra- and inter-cellular communications. A substantial quantity of the available knowledge has only been uncovered in recent years, and we are learning that donor cells release nanovesicles, known as exosomes, which regulate the cellular behavior of recipient cells following uptake. Based on the impressive capacity of exosomes in delivering their "payload", different therapeutic agents, are currently being tested using this delivery method for more effective therapy. This review summarizes the most recent developments in exosome bioactivities and discusses the biochemical nature of exosomes and their biogenesis. It also summarizes the use of exosomes as delivery vehicles for drugs and natural compounds to the targeted site.
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Efficacy of monomeric antitumor components can be enhanced by administration of exosome carriers.
“The efficacy of these monomeric components can be enhanced by the administration of exosome carriers [55].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [55]
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References 76 · Cited by 359
- Authors
- Farooqi, A. A., Desai, N. N., Qureshi, M. Z., Librelotto, D. R. N., Gasparri, M. L., Bishayee, A., Nabavi, S. M., Curti, V., & Daglia, M.
- Affiliations
- Larkin University (US)
- Government College University, Lahore (PK)
- University of Bern (CH)
- Baqiyatallah University of Medical Sciences (IR)
- University of Pavia (IT)
- Corresponding author
- Curti, Valeria
- Daglia, Maria
- ORCID
- Venue
- Biotechnology Advances
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 36
- Issue
- 1
- Pages
- 328-334
- ISSN
- 0734-9750 (ISSN-L)
- OpenAlex
- W2771490038
- Cited by
- 359
- References
- 76
- Citations by year
- 2026: 23 · 2025: 33 · 2024: 60 · 2023: 46 · 2022: 55 · 2021: 56 · 2020: 52 · 2019: 25 · 2018: 7
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biotechnology Advances (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- exosomes, exosome biogenesis, natural compounds, drug delivery, extracellular vesicles, intercellular communication, therapeutic agents
- MeSH terms
- Animals, Curcumin, Humans, Models, Biological, Drug Delivery Systems, Mice, Exosomes, Phytochemicals
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