Cited by 312Enhanced Recovery After SurgeryCardiac, Anesthesia and Surgical OutcomesHemodynamic Monitoring and Therapy

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Prehabilitation in adult patients undergoing surgery: an umbrella review of systematic reviews

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McIsaac, Daniel I., Gill, Marlyn, Boland, Laura, Hutton, Brian, Branje, Karina, Shaw, Julia, Grudzinski, Alexa L., Barone, Natasha, Gillis, Chelsia, Akhtar, Shamsuddin, Atkins, Marlis, Aucoin, Sylvie, Auer, Rebecca, Basualdo-Hammond, Carlota, Beaule, Paul, Brindle, Mary, Bittner, Honorata, Bryson, Gregory, Carli, Franco, Eskander, Antoine, Fata, Paola, Fergusson, Dean, Fiore, Julio, Forster, Alan, Gillam, Melani, Gramlich, Leah, Holroyd-Leduc, Jayna, Jackson, Timothy, Jacobsohn, Eric, Khadaroo, Rachel, Lalu, Manoj, Love, Cameron, Martel, Guillaume, McCartney, Colin, McKeen, Dolores, Meliambro, Amanda, Moloo, Husein, Moore, Ronald, Muscedere, John, Nantel, Julie, Poitras, Stephane, Scheede-Bergdahl, Celena, Taljaard, Monica, Wallace, Tom, Wijeysundera, Duminda·2022·British Journal of Anaesthesia

DOI 10.1016/j.bja.2021.11.014

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Abstract

BACKGROUND The certainty that prehabilitation improves postoperative outcomes is not clear. The objective of this umbrella review (i.e. systematic review of systematic reviews) was to synthesise and evaluate evidence for prehabilitation in improving health, experience, or cost outcomes. METHODS We performed an umbrella review of prehabilitation systematic reviews. MEDLINE, Embase, Cochrane, Cumulative Index to Nursing and Allied Health Literature, PsycINFO, Joanna Briggs Institute's database, and Web of Science were searched (inception to October 20, 2020). We included all systematic reviews of elective, adult patients undergoing surgery and exposed to a prehabilitation intervention, where health, experience, or cost outcomes were reported. Evidence certainty was assessed using Grading of Recommendations Assessment, Development and Evaluation. Primary syntheses of any prehabilitation were stratified by surgery type. RESULTS From 1412 titles, 55 systematic reviews were included. For patients with cancer undergoing surgery who participate in any prehabilitation, moderate certainty evidence supports improvements in functional recovery. Low to very low certainty evidence supports reductions in complications (mixed, cardiovascular, and cancer surgery), non-home discharge (orthopaedic surgery), and length of stay (mixed, cardiovascular, and cancer surgery). There was low to very low certainty evidence that exercise prehabilitation reduces the risk of complications, non-home discharge, and length of stay. There was low to very low certainty evidence that nutritional prehabilitation reduces risk of complications, mortality, and length of stay. CONCLUSIONS Low certainty evidence suggests that prehabilitation may improve postoperative outcomes. Future low risk of bias, randomised trials, synthesised using recommended standards, are required to inform practice. Optimal patient selection, intervention design, and intervention duration must also be determined.

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The PRISMA 2020 statement: An updated guideline for reporting systematic reviews
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., et al. (2021) · BMJ · doi:10.1136/bmj.n71 · Cited by 108,283
Self-citation
Classification of Surgical Complications: A New Proposal With Evaluation in a Cohort of 6336 Patients and Results of a Survey
Dindo, D., Demartines, N., & Clavien, P.-A. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000133083.54934.ae · Cited by 31,378
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305
A typology of reviews: an analysis of 14 review types and associated methodologies
Grant, M. J., & Booth, A. (2009) · Health Information & Libraries Journal · doi:10.1111/j.1471-1842.2009.00848.x · Cited by 10,817
AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both.
Shea, B. J., Reeves, B. C., Wells, G., Thuku, M., Hamel, C., Moran, J., Moher, D., Tugwell, P., Welch, V., Kristjansson, E., et al. (2017) · BMJ · doi:10.1136/bmj.j4008 · Cited by 10,636
PRESS Peer Review of Electronic Search Strategies: 2015 Guideline Statement
McGowan, J., Sampson, M., Salzwedel, D. M., Cogo, E., Foerster, V., & Lefebvre, C. (2016) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2016.01.021 · Cited by 5,700
Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach
Aromataris, E., Fernandez, R., Godfrey, C. M., Holly, C., Khalil, H., & Tungpunkom, P. (2015) · International Journal of Evidence-Based Healthcare · doi:10.1097/xeb.0000000000000055 · Cited by 2,587
GRIPP2 reporting checklists: Tools to improve reporting of patient and public involvement in research
Staniszewska, S., Brett, J., Simera, I., Seers, K., Mockford, C., Goodlad, S., Altman, D. G., Moher, D., Barber, R., Denegri, S., et al. (2017) · BMJ · doi:10.1136/bmj.j3453 · Cited by 1,983
2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery
Fleisher, L. A., Fleischmann, K. E., Auerbach, A. D., Barnason, S. A., Beckman, J. A., Bozkurt, B., Dávila‐Román, V. G., Gerhard‐Herman, M. D., Holly, T. A., Kane, G. C., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.07.944 · Cited by 1,337
Self-citation
GRADE guidelines 26: informative statements to communicate the findings of systematic reviews of interventions
Santesso, N., Glenton, C., Dahm, P., Garner, P., Akl, E. A., Alper, B., Brignardello-Petersen, R., Carrasco-Labra, A., De Beer, H., Hultcrantz, M., et al. (2020) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2019.10.014 · Cited by 1,198

Show all 98 references

Research works printed but not linked: 6

2015, Global surgery 2030 policy brief: assessing access, indicators for a healthy surgical system, Lancet, 386, 569
Thomas, 2019, Prehabilitation before major intra-abdominal cancer surgery: a systematic review of randomised controlled trials, Eur J Anaesthesiol, 36, 933, 10.1097/EJA.0000000000001030 · DOI
Stein, 2015, A atuacao da fisioterapia pre-operatoria em pacientes submetidos a cirurgia de revascularizacao do miocardio: revisao sistematica, Rev Insprirar Moviemento Saude, 7, 20
Nanadkumar, 2020, Outcomes following prehabilitation for major intra-abdominopelvic cancer surgery: a systematic review and meta-analysis of randomised-controlled trials, Art Sci Surg, 107, 1
Simunovic, 2009, Surgery on operative mortality, disease-specific, Can J Surg, 52, 79
McIsaac D.I., An umbrella review of prehabilitation in adult surgical patients. osf.io/8q7c2. Published April 23, 2021. Accessed December 10, 2021.

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Additional file 1 of Does preoperative multidisciplinary team assessment of high-risk patients improve the safety and outcomes of patients undergoing surgery?
Kuiper, B. I., Janssen, L. M. J., Versteeg, K. S., ten Tusscher, B. L., van der Spoel, J. I., Lubbers, W. D., Geert Kazemier, M., Loer, S. A., Schober, P. R., & van Halm, V. P. (2024) · Figshare · doi:10.6084/m9.figshare.26657995
Additional file 2 of Barriers and facilitators to participation in exercise prehabilitation before cancer surgery for older adults with frailty: a qualitative study
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Additional file 4 of PReoperative very low-Energy diets for obese PAtients undergoing non-bariatric surgery Randomized Evaluation (PREPARE): a protocol for a pilot randomized controlled trial
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Additional file 1 of Barriers and facilitators to participation in exercise prehabilitation before cancer surgery for older adults with frailty: a qualitative study
Barnes, K., Hladkowicz, E., Dorrance, K., Bryson, G. L., Forster, A. J., Gagné, S., Huang, A. R., Lalu, M. M., Lavallée, L. T., Saunders, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26594627
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Additional file 1 of PReoperative very low-Energy diets for obese PAtients undergoing non-bariatric surgery Randomized Evaluation (PREPARE): a protocol for a pilot randomized controlled trial
McKechnie, T., Ramji, K., Saddik, M., Leitch, J. K., Farooq, A., Patel, S., Doumouras, A., Parpia, S., Eskicioglu, C., & Bhandari, M. (2024) · Figshare · doi:10.6084/m9.figshare.26723202
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Additional file 4 of Prehabilitation of elderly frail or pre-frail patients prior to elective surgery (PRAEP-GO): study protocol for a randomized, controlled, outcome assessor-blinded trial
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Additional file 2 of PReoperative very low-Energy diets for obese PAtients undergoing non-bariatric surgery Randomized Evaluation (PREPARE): a protocol for a pilot randomized controlled trial
McKechnie, T., Ramji, K., Saddik, M., Leitch, J. K., Farooq, A., Patel, S., Doumouras, A., Parpia, S., Eskicioglu, C., & Bhandari, M. (2024) · Figshare · doi:10.6084/m9.figshare.26723205
Additional file 5 of PReoperative very low-Energy diets for obese PAtients undergoing non-bariatric surgery Randomized Evaluation (PREPARE): a protocol for a pilot randomized controlled trial
McKechnie, T., Ramji, K., Saddik, M., Leitch, J. K., Farooq, A. O., Patel, S., Doumouras, A., Parpia, S., Eskicioglu, C., & Bhandari, M. (2024) · Figshare · doi:10.6084/m9.figshare.26723214
Additional file 6 of Prehabilitation of elderly frail or pre-frail patients prior to elective surgery (PRAEP-GO): study protocol for a randomized, controlled, outcome assessor-blinded trial
Schaller, S. J., Kiselev, J., Loidl, V., Quentin, W., Schmidt, K., Mörgeli, R., Rombey, T., Busse, R., Mansmann, U., & Spies, C. (2022) · Figshare · doi:10.6084/m9.figshare.20012426
Additional file 7 of Prehabilitation of elderly frail or pre-frail patients prior to elective surgery (PRAEP-GO): study protocol for a randomized, controlled, outcome assessor-blinded trial
Schaller, S. J., Kiselev, J., Loidl, V., Quentin, W., Schmidt, K., Mörgeli, R., Rombey, T., Busse, R., Mansmann, U., & Spies, C. (2022) · Figshare · doi:10.6084/m9.figshare.20012429
Additional file 2 of Prehabilitation of elderly frail or pre-frail patients prior to elective surgery (PRAEP-GO): study protocol for a randomized, controlled, outcome assessor-blinded trial
Schaller, S. J., Kiselev, J., Loidl, V., Quentin, W., Schmidt, K., Mörgeli, R., Rombey, T., Busse, R., Mansmann, U., & Spies, C. (2022) · Figshare · doi:10.6084/m9.figshare.20012414
Additional file 5 of Prehabilitation of elderly frail or pre-frail patients prior to elective surgery (PRAEP-GO): study protocol for a randomized, controlled, outcome assessor-blinded trial
Schaller, S. J., Kiselev, J., Loidl, V., Quentin, W., Schmidt, K., Mörgeli, R., Rombey, T., Busse, R., Mansmann, U., & Spies, C. (2022) · Figshare · doi:10.6084/m9.figshare.20012423
Additional file 1 of Prehabilitation of elderly frail or pre-frail patients prior to elective surgery (PRAEP-GO): study protocol for a randomized, controlled, outcome assessor-blinded trial
Schaller, S. J., Kiselev, J., Loidl, V., Quentin, W., Schmidt, K., Mörgeli, R., Rombey, T., Busse, R., Mansmann, U., & Spies, C. (2022) · Figshare · doi:10.6084/m9.figshare.20012411
Additional file 2 of Barriers and facilitators to smartwatch-based prehabilitation participation among frail surgery patients: a qualitative study
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Additional file 3 of Barriers and facilitators to participation in exercise prehabilitation before cancer surgery for older adults with frailty: a qualitative study
Barnes, K., Hladkowicz, E., Dorrance, K., Bryson, G. L., Forster, A. J., Gagné, S., Huang, A. R., Lalu, M. M., Lavallée, L. T., Saunders, C., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26594639
Self-citation
Additional file 1 of Barriers and facilitators to smartwatch-based prehabilitation participation among frail surgery patients: a qualitative study
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Additional file 3 of Prehabilitation of elderly frail or pre-frail patients prior to elective surgery (PRAEP-GO): study protocol for a randomized, controlled, outcome assessor-blinded trial
Schaller, S. J., Kiselev, J., Loidl, V., Quentin, W., Schmidt, K., Mörgeli, R., Rombey, T., Busse, R., Mansmann, U., & Spies, C. (2022) · Figshare · doi:10.6084/m9.figshare.20012417
Additional file 3 of PReoperative very low-Energy diets for obese PAtients undergoing non-bariatric surgery Randomized Evaluation (PREPARE): a protocol for a pilot randomized controlled trial
McKechnie, T., Ramji, K., Saddik, M., Leitch, J. K., Farooq, A., Patel, S., Doumouras, A., Parpia, S., Eskicioglu, C., & Bhandari, M. (2024) · Figshare · doi:10.6084/m9.figshare.26723208
Additional file 1 of Barriers and facilitators to the implementation of prehabilitation for elderly frail patients prior to elective surgery: a qualitative study with healthcare professionals
Fuchs, T. I., Pfab, C., Kiselev, J., Schaller, S. J., Spies, C., & Rombey, T. (2024) · Figshare · doi:10.6084/m9.figshare.26712971
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Authors: McIsaac, D. I., Gill, M., Boland, L., Hutton, B., Branje, K., Shaw, J., Grudzinski, A. L., Barone, N., Gillis, C., Akhtar, S., Atkins, M., Aucoin, S., Auer, R., Basualdo-Hammond, C., Beaule, P., Brindle, M., Bittner, H., Bryson, G., Carli, F., Eskander, A., Fata, P., Fergusson, D., Fiore, J., Forster, A., Gillam, M., Gramlich, L., Holroyd-Leduc, J., Jackson, T., Jacobsohn, E., Khadaroo, R., Lalu, M., Love, C., Martel, G., McCartney, C., McKeen, D., Meliambro, A., Moloo, H., Moore, R., Muscedere, J., Nantel, J., Poitras, S., Scheede-Bergdahl, C., Taljaard, M., Wallace, T., & Wijeysundera, D.
Affiliations: University of Ottawa (CA)
University of Calgary (CA)
Ottawa Hospital Research Institute (CA)
McGill University (CA)
Yale University (US)
Alberta Health Services (CA)
Ottawa Hospital (CA)
Sunnybrook Hospital (CA)
University of Alberta (CA)
University Health Network (CA)
University of Manitoba (CA)
Memorial University of Newfoundland (CA)
Carleton University (CA)
Kingston General Hospital (CA)
University of British Columbia (CA)
St. Michael's Hospital (CA)
Corresponding author: McIsaac, Daniel I.
Akhtar, Shamsuddin
Atkins, Marlis
Aucoin, Sylvie
Auer, Rebecca
Brindle, Mary
Bittner, Honorata
Bryson, Gregory
Carli, Franco
Eskander, Antoine
Fata, Paola
Fergusson, Dean
Fiore, Julio
Forster, Alan
Gillam, Melani
Gramlich, Leah
Holroyd-Leduc, Jayna
Jackson, Timothy
Jacobsohn, Eric
Khadaroo, Rachel
Lalu, Manoj
Love, Cameron
Martel, Guillaume
McCartney, Colin
McKeen, Dolores
Meliambro, Amanda
Moloo, Husein
Moore, Ronald
Muscedere, John
Nantel, Julie
Taljaard, Monica
Wallace, Tom
Wijeysundera, Duminda
ORCID: McIsaac, Daniel I.
Boland, Laura
Hutton, Brian
Branje, Karina
Shaw, Julia
Grudzinski, Alexa L.
Barone, Natasha
Gillis, Chelsia
Akhtar, Shamsuddin
Aucoin, Sylvie
Auer, Rebecca
Brindle, Mary
Bryson, Gregory
Carli, Franco
Eskander, Antoine
Fata, Paola
Fergusson, Dean
Fiore, Julio
Forster, Alan
Gillam, Melani
Gramlich, Leah
Holroyd-Leduc, Jayna
Jackson, Timothy
Jacobsohn, Eric
Khadaroo, Rachel
Lalu, Manoj
Martel, Guillaume
McCartney, Colin
McKeen, Dolores
Moloo, Husein
Moore, Ronald
Muscedere, John
Nantel, Julie
Taljaard, Monica
Wallace, Tom
Wijeysundera, Duminda
Venue: British Journal of Anaesthesia
Publisher: Elsevier BV
Published: 2022-02
Volume: 128
Issue: 2
Pages: 244-257
ISSN: 0007-0912 (ISSN-L)
DOI: 10.1016/j.bja.2021.11.014
OpenAlex: W4200413066
Semantic Scholar: ea56e19fb012b851f938df9f748371f43e1fef37
Cited by: 312
References: 98
Citations by year: 2026: 69 · 2025: 82 · 2024: 78 · 2023: 44 · 2022: 39
FWCI: 9.70
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 365 d)
Locations: British Journal of Anaesthesia (publishedVersion)
PubMed (publishedVersion)
Funders: Ottawa Hospital Anesthesia Alternate Funds Association
Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac, Anesthesia and Surgical Outcomes
Health Sciences › Medicine › Surgery › Hemodynamic Monitoring and Therapy
Keywords: prehabilitation, elective surgery, postoperative outcomes, cancer surgery, exercise prehabilitation, nutritional prehabilitation, postoperative complications, length of hospital stay, functional recovery, non-home discharge, cardiovascular surgery, orthopedic surgery, patient selection
MeSH terms: Systematic Reviews as Topic, Preoperative Exercise, Adult, Humans, Length of Stay, Postoperative Complications, Randomized Controlled Trials as Topic, Elective Surgical Procedures, Patient Selection, Nutrition Therapy

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Prehabilitation in adult patients undergoing surgery: an umbrella review of systematic reviews

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