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The role of blood rheology in sickle cell disease

Open access
Connes, Philippe, Alexy, Tamas, Detterich, Jon, Romana, Marc, Hardy-Dessources, Marie-Dominique, Ballas, Samir K.·2016·Blood Reviews

Abstract

Studies performed in the last decades have highlighted the need to better understand the contribution of the endothelium, vascular function, oxidative stress, inflammation, coagulation, hemolysis and vascular adhesion mechanisms to the pathophysiology of acute vaso-occlusive like events and chronic organ damages in sickle cell disease (SCD). Although SCD is a hemorheological disease, a few works focused on the contribution of blood viscosity, plasma viscosity, red blood cell deformability and aggregation in the pathophysiology of SCD. After a brief description of basic hemorheology, the present review focuses on the role of the hemorheological abnormalities in the causation of several SCD complications, mainly in sickle cell anemia and hemoglobin (Hb) SC disease. Several genetic and cellular modulators of blood rheology in SCD are discussed, as well as unresolved questions and perspectives.

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Metadata

Authors
Connes, P., Alexy, T., Detterich, J., Romana, M., Hardy-Dessources, M.-D., & Ballas, S. K.
Venue
Blood Reviews
Publisher
Elsevier BV
Published
2016-03
Volume
30
Issue
2
Pages
111-118
ISSN
0268-960X (ISSN-L)
OpenAlex
W1608618361
Cited by
225
References
11
FWCI
6.52
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The role of blood rheology in sickle cell disease. https://app.cochat.ai/papers/10.1016/j.blre.2015.08.005
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Connes, P., Alexy, T., Detterich, J., Romana, M., Hardy-Dessources, M.-D., & Ballas, S. K. (2016). The role of blood rheology in sickle cell disease. Blood Reviews. https://doi.org/10.1016/j.blre.2015.08.005

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.