Hydrogen sulfide induces nitric oxide release from nitrite
Abstract
Hydrogen sulfide has recently been considered to have an important role as a gasotransmitter in the cardiovascular system as well as in the central nervous system, but its action seems directly related to the presence of nitric oxide/nitric oxide-derivatives. We report here chemical evidence that emphasizes a prominent role of the hydrogen sulfide as cofactor of NO-derivatives in inducing nitric oxide release.
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Under acidic conditions, the reaction of sulfide with nitrite leads to a range of nitrogen- and sulfur-containing products.
“There is a considerable amount of lesser-known older work on the reaction of sulfide with nitrite demonstrating that under acidic conditions the reaction leads to a range of products.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [31]
Earlier studies showed that nitrite can be reduced to NO following direct reaction with sulfide.
“However, sulfide may facilitate nitrite reduction to NO via interaction with Fe 3+ protoporphyrin [30], while earlier studies showed that nitrite can be reduced to NO following direct reaction with sulfide [31,32].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [31]
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References 22 · Cited by 35
- Authors
- Grossi, L.
- Affiliations
- University of Bologna (IT)
- Corresponding author
- Grossi, Loris
- ORCID
- Grossi, Loris
- Venue
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 19
- Issue
- 21
- Pages
- 6092-6094
- ISSN
- 0960-894X (ISSN-L)
- OpenAlex
- W2158750197
- Cited by
- 35
- References
- 22
- Citations by year
- 2026: 1 · 2023: 1 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 1 · 2012: 1
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioorganic & Medicinal Chemistry Letters (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and Reactivity of Sulfur-Containing Compounds
- Keywords
- hydrogen sulfide, nitric oxide, nitrite, gasotransmitters, nitric oxide derivatives, cofactors, nitric oxide release
- MeSH terms
- Cardiovascular Diseases, Cardiovascular System, Central Nervous System, Central Nervous System Diseases, Hydrogen Sulfide, Hydrogen-Ion Concentration, Nitric Oxide, Sodium Nitrite
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