The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Fluoride enhances the activity of fungicides that destabilize cell membranes
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In both prokaryotic and eukaryotic microorganisms, fluoride potentiates the effect of drugs that inhibit cell wall biosynthesis.
“In both prokaryotic and eukaryotic microorganisms, fluoride potentiates the effect of drugs that inhibit cell wall biosynthesis109–111.”
From The link between ancient microbial fluoride resistance mechanisms and bioengineering organofluorine degradation or synthesis (2024) · cites this paper as [109]
Amphotericin B increases fluoride toxicity to fungal cells presumably by allowing fluoride to pass either way across cell membranes, resulting in enhanced fluoride toxicity.
“By contrast, amphotericin B increases fluoride toxicity to fungal cells presumably by allowing fluoride to pass either way across cell membranes, resulting in enhanced fluoride toxicity (Zasloff and Steinberg, 1993; Li and Breaker, 2012).”
From Small Molecule Fluoride Toxicity Agonists (2015) · cites this paper as Li and Breaker, 2012
There is precedence for compounds that disrupt membrane integrity to enhance fluoride toxicity.
“There is precedence for compounds that disrupt membrane integrity to enhance fluoride toxicity (Li and Breaker, 2012; Nelson et al., 2014; Zasloff and Steinberg, 1993).”
From Small Molecule Fluoride Toxicity Agonists (2015) · cites this paper as Li and Breaker, 2012
Some previously characterized pore-forming antibacterial and antifungal compounds have been demonstrated to enhance the cytotoxic activity of fluoride.
“This speculation is supported by the fact that some previously characterized pore-forming antibacterial and antifungal compounds have been demonstrated to enhance the cytotoxic activity of fluoride (Li and Breaker, 2012; Nelson et al., 2014; Zasloff and Steinberg, 1993).”
From Small Molecule Fluoride Toxicity Agonists (2015) · cites this paper as Li and Breaker, 2012
Existing molecules only modestly increase fluoride toxicity.
“However, these existing molecules only modestly increase fluoride toxicity, and no non-peptidic molecules have been identified that increase fluoride toxicity towards bacteria.”
From Small Molecule Fluoride Toxicity Agonists (2015) · cites this paper as Li and Breaker, 2012
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The Pfam protein families database
Finn, R. D., Mistry, J., Tate, J., Coggill, P., Heger, A., Pollington, J. E., Gavin, O. L., Gunasekaran, P., Ceric, G., Forslund, K., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp985 · Cited by 2,694
Compounds active against cell walls of medically important fungi
Hector, R. F. (1993) · Clinical Microbiology Reviews · doi:10.1128/cmr.6.1.1 · Cited by 242
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Cited by
Sorted by citations
Stockbridge, R. B., & Wackett, L. P. (2024) · Nature Communications · doi:10.1038/s41467-024-49018-1 · Cited by 80
Membrane exporters of fluoride ion
McIlwain, B. C., Ruprecht, M. T., & Stockbridge, R. B. (2021) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-071520-112507 · Cited by 69
Small Molecule Fluoride Toxicity Agonists
Nelson, J. W., Plummer, M. S., Blount, K. F., Ames, T. D., & Breaker, R. R. (2015) · Chemistry & Biology · doi:10.1016/j.chembiol.2015.03.016 · Cited by 30
Self-citation
Metadata
- Authors
- Li, S., & Breaker, R. R.
- Venue
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 22
- Issue
- 9
- Pages
- 3317-3322
- ISSN
- 0960-894X
- PMC
- PMC4498161
- Cited by
- 36
- References
- 2
- Language
- en
- Licence
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (GM022778)
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