Reduction in proximal femoral strength due to long-duration spaceflight

Cited by (236)

Items 101–200 of 236

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2. Finite Element Analysis of the Hip and Spine Based on Quantitative Computed Tomography
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3. Partial gravity unloading inhibits bone healing responses in a large animal model
   Benjamin C. Gadomski, Kirk C. McGilvray, Jeremiah T. Easley, Ross H. Palmer, Brandon G. Santoni, Christian M. Puttlitz · 2014 · Journal of Biomechanics
4. Patient-Specific Bone Multiscale Modelling, Fracture Simulation and Risk Analysis—A Survey
   Amadeus C. S. de Alcântara, Israel Assis, Daniel Prada, Konrad Mehle, Stefan Schwan, Lúcia Costa‐Paiva, Munir S. Skaf, Luiz Carlos Wrobel, Paulo Sollero · 2019 · Materials
5. Effects of Muscles on Bone Metabolism—with a Focus on Myokines
   Beom‐Jun Kim · 2022 · Annals of Geriatric Medicine and Research
6. A novel numerical model for the prediction of patient-dependent bone density loss in microgravity based on micro-CT images
   Amirhossein Bagherian, Mostafa Baghani, Daniel George, Yves Rémond, Christine Chappard, С. А. Патлажан, Majid Baniassadi · 2019 · Continuum Mechanics and Thermodynamics
7. Understanding vestibular-related physiological functions could provide clues on adapting to a new gravitational environment
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8. Bone Imaging and Fracture Risk after Spinal Cord Injury
   William Brent Edwards, Thomas J. Schnitzer · 2015 · Current Osteoporosis Reports
9. Four weeks of training in a sledge jump system improved the jump pattern to almost natural reactive jumps
   Andreas Krämer, Ramona Ritzmann, Markus Grüber, Albert Gollhofer · 2011 · European Journal of Applied Physiology
10. The combined effects of X-ray radiation and hindlimb suspension on bone loss
    Dawei Xu, Xin Zhao, Y. Li, Yan Ji, J. Zhang, J. Wang, Xiaojie Xie, Guangming Zhou · 2014 · Journal of Radiation Research
11. Gravity, Microgravity and Artificial Gravity: Physiological Effects, Implementation and Applications
    Goswami, Nandu, Blaber, Andrew Philip, Valenti, Giovanna, Hinghofer-Szalkay, Helmut, Evans, Joyce, Bailey, Damian Miles, Vernikos, Joan, Choukér, Alexander, Green, David Andrew, White, Olivier et al. · 2026 · Physiological Reviews
12. Response and adaptation of bone cells to simulated microgravity
    Lifang Hu, Runzhi Li, Peihong Su, Yasir Arfat, Ge Zhang, Peng Shang, Airong Qian · 2014 · Acta Astronautica
13. Increased training loads do not magnify cancellous bone gains with rodent jump resistance exercise
    Joshua M. Swift, Heath G. Gasier, Sibyl N. Swift, Michael P. Wiggs, Harry A. Hogan, James D. Fluckey, Susan A. Bloomfield · 2010 · Journal of Applied Physiology
14. Human Response to Space Flight
    Ellen Baker, Michael R. Barratt, Clarence F. Sams, Mary L. Wear · 2019 · Springer eBooks
15. Connexin 43 hemichannels and prostaglandin E2 release in anabolic function of the skeletal tissue to mechanical stimulation
    Dezhi Zhao, Jiawei Wu, Francisca M. Acosta, Huiyun Xu, Jean Xin Jiang · 2023 · Frontiers in Cell and Developmental Biology
16. Micro-finite element analysis applied to high-resolution MRI reveals improved bone mechanical competence in the distal femur of female pre-professional dancers
    Gregory A. Chang, Chamith S. Rajapakse, Matthew C. Diamond, Stephen Honig, Michael P. Recht, D. S. Weiss, Ravinder Reddy Regatte · 2012 · Osteoporosis International
17. Measuring bone mineral density with fat–water MRI: comparison with computed tomography
    Kai‐Yu Ho, Peng Hu, Joyce H. Keyak, Patrick M. Colletti, Christopher M. Powers · 2012 · Journal of Magnetic Resonance Imaging
18. β-1 Adrenergic Agonist Mitigates Unloading-Induced Bone Loss by Maintaining Formation
    Joshua M. Swift, Harry A. Hogan, Susan A. Bloomfield · 2013 · Medicine & Science in Sports & Exercise
19. Acute exposure to microgravity does not influence the H-reflex with or without whole body vibration and does not cause vibration-specific changes in muscular activity
    Andreas Krämer, Albert Gollhofer, Ramona Ritzmann · 2013 · Journal of Electromyography and Kinesiology
20. Heterogeneous Spatial and Strength Adaptation of the Proximal Femur to Physical Activity: A Within-Subject Controlled Cross-Sectional Study
    Stuart J. Warden, Julio Carballido‐Gamio, Alyssa M. Weatherholt, Joyce H. Keyak, Chenxi Yan, Mariana E. Kersh, Thomas Lang, Robyn K. Fuchs · 2019 · Journal of Bone and Mineral Research
21. Strategies of Manipulating BMP Signaling in Microgravity to Prevent Bone Loss
    Jamila H. Siamwala, Saranya Rajendran, Suvro Chatterjee · 2015 · Vitamins and hormones
22. Differential Bone Adaptation to Mechanical Unloading and Reloading in Young, Old, and Osteocyte Deficient Mice
    Hailey C. Cunningham, Sophie V. Orr, Deepa K. Murugesh, Allison W. Hsia, Benjamin Osipov, Lauren Go, Po Hung Wu, Alice Wong, Gabriela G. Loots, Galateia J. Kazakia et al. · 2022 · Bone
23. The Physiology and Pathophysiology of the Osteoclast
    Barbara Peruzzi, Anna Maria Teti · 2011 · Clinical Reviews in Bone and Mineral Metabolism
24. Lower-body negative pressure restores leg bone microvascular flow to supine levels during head-down tilt
    Jamila H. Siamwala, Paul C. Lee, Brandon Richard Macias, Alan R. Hargens · 2015 · Journal of Applied Physiology
25. Osteoblast versus Adipocyte: Bone Marrow Microenvironment-Guided Epigenetic Control
    Jiao Li, Bin Zuo, Li Zhang, Liming Dai, Xiaoling Zhang · 2018 · Case Reports in Orthopedic Research
26. Gene-metabolite networks associated with impediment of bone fracture repair in spaceflight
    Nabarun Chakraborty, Ariane Zamarioli, Aarti Gautam, Ross Campbell, Stephen Kyle Mendenhall, Paul Childress, George I. Dimitrov, Bintu Sowe, Aamir Tucker, Liming Zhao et al. · 2021 · Computational and Structural Biotechnology Journal
27. A Functional Interplay between 5-Lipoxygenase andμ-Calpain Affects Survival and Cytokine Profile of Human Jurkat T Lymphocyte Exposed to Simulated Microgravity
    Valeria Gasperi, Cinzia Rapino, Natalia Battista, Monica Bari, Nicolina Mastrangelo, Silvia Angeletti, Enrico Dainese, Mauro Maccarrone · 2014 · BioMed Research International
28. Previous exposure to simulated microgravity does not exacerbate bone loss during subsequent exposure in the proximal tibia of adult rats
    Yasaman Shirazi‐Fard, Rachel A. Anthony, Andrea T. Kwaczala, Stefan Judex, Susan A. Bloomfield, Harry A. Hogan · 2013 · Bone
29. Population analysis of space travelers
    Tatsuya Corlett, Mariya Stavnichuk, Svetlana V. Komarova · 2020 · Life Sciences in Space Research
30. Microgravity, Stem Cells, and Embryonic Development: Challenges and Opportunities for 3D Tissue Generation
    Massimiliano Andreazzoli, Debora Angeloni, Vania Broccoli, Gian Carlo Demontis · 2017 · Frontiers in Astronomy and Space Sciences
31. Approaching Gravity as a Continuum Using the Rat Partial Weight-Bearing Model
    Marie Mortreux, Megan E. Rosa‐Caldwell · 2020 · Life
32. miR-138–5p negatively regulates osteoblast differentiation through inhibiting β-catenin under simulated microgravity in MC3T3-E1 cells
    Zhihao Chen, Yan Zhang, Fan Zhao, Chong Yin, Chaofei Yang, Ying Huai, Shujing Liang, Shuyu Liu, Xia Xu, Zixiang Wu et al. · 2021 · Acta Astronautica
33. Inhibitory effect of simulated microgravity on differentiating preosteoblasts
    Lifang Hu, Airong Qian, Y. Wang, S.M. Di, P. Shang · 2012 · Advances in Space Research
34. Mitogen-activated protein kinase phosphatase-1: function and regulation in bone and related tissues
    David Tyler Broome, Nabanita S. Datta · 2016 · Connective Tissue Research
35. Zoledronic acid after spinal cord injury mitigates losses in proximal femoral strength independent of ambulation ability
    Laura E. Crack, Ifaz T. Haider, Narina Simonian, Joana Barroso, Leigh Gabel, Thomas J. Schnitzer, William Brent Edwards · 2023 · Osteoporosis International
36. Gene Expression Microarrays in Microgravity Research: Toward the Identification of Major Space Genes
    Q. Jade · 2012 · InTech eBooks
37. Gender differences in tibial microvascular flow responses to head down tilt and lower body negative pressure
    Jamila H. Siamwala, Brandon Richard Macias, Paul C. Lee, Alan R. Hargens · 2017 · Physiological Reports
38. Hip load capacity cut-points for Astronaut Skeletal Health NASA Finite Element Strength Task Group Recommendations
    Andrew S. Michalski, Shreyasee Amin, Angela M. Cheung, DIANNA DICKIE CODY, Joyce H. Keyak, Thomas Lang, Daniel P. Nicolella, ERIC S. ORWOLL, Steven K. Boyd, Jean D. Sibonga · 2019 · npj Microgravity
39. Application of the Brinkley Dynamic Response Criterion to Spacecraft Transient Dynamic Events
    Jeffrey T. Somers, Dustin M. Gohmert, James W. Brinkley · 2017 · NASA Technical Reports Server (NASA)
40. Ishophloroglucin A Ameliorates VEGF-Induced Epithelial-Mesenchymal Transition via VEGFR2 Pathway Inhibition in Microgravity-Stimulated Human Retinal Pigment Epithelial Cells
    Myeongjoo Son, BoMi Ryu, Jun-Geon Je, You‐Jin Jeon, Dae Yu Kim · 2022 · Antioxidants
41. Altered rodent gait characteristics after ~35 days in orbit aboard the International Space Station
    Andy T. Kwok, Samuel Rosas, Ted A. Bateman, Eric W. Livingston, Thomas L. Smith, Joseph Moore, David Carl Zawieja, Tom G. Hampton, Xiao Wen Mao, Michael D. Delp et al. · 2019 · Life Sciences in Space Research
42. Immobilization Osteoporosis
    William A. Bauman, Christopher P. Cardozo · 2013 · Elsevier eBooks
43. Musculoskeletal Response to Space Flight
    Linda C. Shackelford · 2019 · Springer eBooks
44. Gap Junctions and Biophysical Regulation of Bone Cells
    Shane A. J. Lloyd, Henry J. Donahue · 2010 · Clinical Reviews in Bone and Mineral Metabolism
45. The application of micro-CT in monitoring bone alterations in tail-suspended rats in vivo
    Huiqin Luan, Lianwen Sun, Yunfei Huang, Ying Wang, Colin Joseph McClean, Yubo Fan · 2014 · Advances in Space Research
46. Living and Working in Space: An Overview of Physiological Adaptation, Performance, and Health Risks
    ARNAULD E. NICOGOSSIAN, Richard S. Williams, Carolyn L. Huntoon, Charles R. Doarn · 2016 · Springer eBooks
47. Physical activity induced adaptation can increase proximal femur strength under loading from a fall onto the greater trochanter
    Robyn K. Fuchs, Julio Carballido‐Gamio, Joyce H. Keyak, Mariana E. Kersh, Stuart J. Warden · 2021 · Bone
48. Anatomically reproducible assessment of volumetric bone mineral density — Based on clinical computed tomography
    Yeon Soo Lee, Terihisa Mihata, Joo Han Oh · 2012 · Journal of Biomechanics
49. Multi-scale numerical simulation on mechano-transduction of osteocytes in different gravity fields
    Chaohui Zhao, Haiying Liu, Congbiao Tian, Chunqiu Zhang, Wei Wang · 2022 · Computer Methods in Biomechanics & Biomedical Engineering
50. Simulated lesions representative of metastatic disease predict proximal femur failure strength more accurately than idealized lesions
    Joshua E. Johnson, Marc James Brouillette, Palani Permeswaran, Benjamin James Miller, Jessica E. Goetz · 2020 · Journal of Biomechanics
51. Redox-regulated bone loss in spaceflight and terrestrial models: Molecular mechanisms and therapeutic strategies
    Gianfranco Pintus, Mohammed A. Akram, Roberta Giordo, Gianfilippo Caggiari, Amin F. Majdalawieh · 2025 · Free Radical Biology and Medicine
52. A new hip fracture risk index derived from FEA-computed proximal femur fracture loads and energies-to-failure
    Xuewei Cao, Joyce H. Keyak, Sigurdur Oli Sigurdsson, Zhao Chen, Weihua Zhou, Anqi Liu, Thomas Lang, Hong‐Wen Deng, Vilmundur G. Gudnason, Qiuying Sha · 2024 · Osteoporosis International
53. Prediction of micro-scale bone adaptation of human trabecular bone under different implanted conditions
    Masud Rana, Santanu Kumar Karmakar, Nico J. J. Verdonschot, Amit Roy Chowdhury · 2024 · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials
54. High-Resolution Imaging Techniques for Bone Quality Assessment
    Andrew J. Burghardt, Roland Krug, Sharmila Majumdar · 2017 · Elsevier eBooks
55. Changes in the astronaut serum proteome during prolonged spaceflight
    Yayoi Kimura, Yusuke Nakai, Yoko Ino, Tomoko Hayashi Akiyama, Kayano Moriyama, Tatsuya Aiba, Takashi Ohira, Kenji Egashira, Yu Yamamoto, Yuriko Takeda et al. · 2024 · PROTEOMICS
56. Microgravity Stress: Bone and Connective Tissue
    Susan A. Bloomfield, Daniel A. Martinez, Ramon D. Boudreaux, Anita V. Mantri · 2016 · Comprehensive physiology
57. Electroacupuncture stimulation at BL20, BL23 and SP6 prevents hind limb unloading–induced osteoporosis in rats
    Honghui Wang, Desheng Wang, Zhili Li, Shujuan Liu, Jingjing Dong, Jianfeng Zhang, Huijuan Wang, Minjie Wang, Bo Ji, Yinghui Li · 2021 · Acupuncture in Medicine
58. PRINCIPLES OF SINGLE-MOLECULE MANIPULATION AND ITS APPLICATION IN BIOLOGICAL PHYSICS
    Wei‐Hung Chen, Jonathan D. Wilson, Sithara S. Wijeratne, SARAH A. SOUTHMAYD, Kuan‐Jiuh Lin, Ching‐Hwa Kiang · 2012 · International Journal of Modern Physics B
59. Bone densitometry and true BMD accuracy for predicting fractures: what are the alternatives?
    Harri T. Sievänen · 2010 · International Journal of Clinical Rheumatology
60. Effects of hypergravity on gene levels in anti-gravity muscle and bone through the vestibular system in mice
    Naoyuki Kawao, Hironobu Morita, Kazuaki Nishida, Koji Obata, Kohei Tatsumi, Hiroshi Kaji · 2017 · The Journal of Physiological Sciences
61. Human spaceflight and space adaptations: Computational simulation of gravitational unloading on the spine
    Molly T. Townsend, Nesrin Sarigul‐Klijn · 2018 · Acta Astronautica
62. Severe bone microarchitecture deterioration in a family with hereditary neuropathy: evidence of the key role of the mechanostat
    Rubén Abdala, L. Levi, Vanesa Longobardi, María Belén Zanchetta · 2020 · Osteoporosis International
63. Bone deconditioning during partial weight-bearing in rodents – A systematic review and meta-analysis
    Patrick Swain, Marie Mortreux, Jonathan M. Laws, Harry Kyriacou, Enrico De Martino, Andrew Winnard, Nick Caplan · 2022 · Life Sciences in Space Research
64. Lycium barbarum Polysaccharide Ameliorates Hindlimb Unloading‐Induced Bone Loss by Targeting Noggin
    Chuanxin Sun, Yuke He, Xia Chen, Kan Ding, Chang Chen · 2025 · The FASEB Journal
65. The bone alterations in hind limb amputation rats in vivo
    Huiqin Luan, Huiru Gu, Zhongjun Mo, Weiyan Ren, Huan Guo, Zhaowei Chu, Yubo Fan · 2020 · Medicine in Novel Technology and Devices
66. Bone loss during partial weight bearing (1/6th gravity) is mitigated by resistance and aerobic exercise in mice
    Ramon D. Boudreaux, Corinne E. Metzger, Brandon Richard Macias, Yasaman Shirazi‐Fard, Harry A. Hogan, Susan A. Bloomfield · 2014 · Acta Astronautica
67. Modeling the benefits of an artificial gravity countermeasure coupled with exercise and vibration
    Rahul Goel, Justin Kaderka, Dava J. Newman · 2011 · Acta Astronautica
68. Compact MRI for Astronaut Physiological Research and Medical Diagnosis
    Gordon E. Sarty, Saija Annukka Kontulainen, Adam D. G. Baxter-Jones, Roger A. Pierson, K. Turek, André Obenaus, Bogusław Tomanek, Jonathan C. Sharp, Alan Scott, Louis Piche · 2012 · AIAA SPACE Conference & Exposition
69. High-Resolution Imaging Techniques for Bone Quality Assessment
    Andrew J. Burghardt, Roland Krug, Sharmila Majumdar · 2011 · Elsevier eBooks
70. Perspective: skeletal complications of space flight
    Edward F. McCarthy · 2011 · Skeletal Radiology
71. Understanding Bone Strength from Finite Element Models: Concepts for Non-engineers
    Christopher J. Hernandez, Erin N. Cresswell · 2016 · Clinical Reviews in Bone and Mineral Metabolism
72. A reproducible radiation delivery method for unanesthetized rodents during periods of hind limb unloading
    Matthew C. Walb, Paul J. Black, Valerie S. Payne, Michael T. Munley, Jeffrey S. Willey · 2015 · Life Sciences in Space Research
73. Basolateral Amygdala Mediates Central Mechanosensory Feedback of Musculoskeletal System
    Nian Liu, Botai Li, Lu Zhang, Dazhi Yang, Fan Yang · 2022 · Frontiers in Molecular Neuroscience
74. αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading
    Jeffrey S. Willey, Serena M. Auñón-Chancellor, Lauren A. Miles, Joseph E. Moore, Xiao Wen Mao, Robert W. Wallace, Matthew C. Foy · 2022 · npj Microgravity
75. Effects of spaceflight on cancellous and cortical bone in proximal femur in growing rats
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76. Stability of a Rotating Asteroid Housing a Space Station
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77. Peri-flight Neuromusculoskeletal Injuries in Astronauts
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78. Effects of whole body vibration on prevention of bone loss in 8-week tail-suspended male rats
    Cheng Tan, Wei Su, Chao Ma, Zhili Li, Huijuan Wang, Wenjuan Chen, Zheng Ke, Ming Zhang · 2010 · International Conference on Biomedical Engineering and Informatics (BMEI)
79. Finite Element Simulation of Fracture Profile of Bone Material: A Case of Study Applied to Human Femur Specimen
    Awad Bettamer, Ridha Hambli · 2015 · Elsevier eBooks
80. Extending Rest between Unloading Cycles Does Not Enhance Bone’s Long-Term Recovery
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81. Mapping Bone Mineral Density Obtained by Quantitative Computed Tomography to Bone Volume Fraction
    James A. Pennline, Lealem Mulugeta · 2017 · NASA Technical Reports Server (NASA)
82. Immobilization osteoporosis
    Christopher P. Cardozo, William A. Bauman · 2020 · Elsevier eBooks
83. Using functionally characterized networks in the application of precision medicine in spaceflight
    Michael A. Schmidt, Julian C. Schmidt · 2025 · Elsevier eBooks
84. Essentials of Bone Biology
    Thomas Lang · 2010 · Elsevier eBooks
85. Effect of Laser Acupuncture Therapy on Bone and Articular Cartilage under Simulated Microgravity
    Qian-Cheng Wang, Xia Guo, X. Y. Wang, M. Q. Liu, Ming Zhang, Yong‐Ping Zheng, H.C. Man · 2010 · World Congress on Medical Physics and Biomedical Engineering, September 7 - 12, 2009, Munich, Germany
86. A Computational Model for Simulating Spaceflight Induced Bone Remodeling
    James A. Pennline, Lealem Mulugeta · 2014 · NASA STI Repository (National Aeronautics and Space Administration)
87. Biology of Bone and the Interaction of Bone with Other Organ Systems
    David M. Findlay · 2017 · Courses and lectures
88. Forecasting Postflight Hip Fracture Probability Using Probabilistic Modeling
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89. Finite Element Analysis of A Hip Joint Prosthesis with An Extramedullary Fixation System
    Mahdi Ebrahimkhani, A. Abbasi-Ghiri, Farzam Farahmand · 2020 · National and International Iranian Conference on Biomedical Engineering (ICBME)
90. Space and Aging
    J. Vernikos-Danellis · 2020 · Springer eBooks
91. Evaluating Daily Load Stimulus Formulas in Relating Bone Response to Exercise
    James A. Pennline, Lealem Mulugeta · 2014 · NASA Technical Reports Server (NASA)
92. Aging
    J. Vernikos-Danellis · 2017 · Springer eBooks
93. Effects of prolonged confined space operations on human gut microbiota and serum metabolome
    Sun Fuqiang, Geli Qin, Zeng Hao, Miaosheng Guan, Hui Liu, Hongjie Qiu, Tiantian Wei, Haisheng Hu · 2025 · Human Nutrition & Metabolism
94. Spaceflight and Fractures: 5-Year-Fracture Incidence Upon Return From Spaceflight
    Benjamin Fiedler, Nathaniel Grey Loyd, Joshua Morrow, Nicholas J. Cione, Abdullah N. Ghali, Brenden B. Ronna, Adil Shahzad Ahmed · 2026 · Wilderness and Environmental Medicine
95. Personalized Medicine in Space Flight, Part II
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96. Space and Aging
    J. Vernikos-Danellis · 2021 · Springer eBooks
97. Numerical modeling of degraded microstructures
    Majid Baniassadi, Mostafa Baghani, Yves Rémond · 2023 · Elsevier eBooks
98. Long Duration Space Flight Exposed Whole Human Spine: Biomechanical Changes Predictions
    Molly T. Townsend, Nesrin Sarigul‐Klijn · 2016 · AIAA SPACE 2016
99. The Influence of Microgravity to Pathology and Physiology of the Eye
    Jing Li, Weiwei Chen, Ningli Wang, Gangwei Cheng · 2019 · Advances in visual science and eye diseases
100. Bone Loss
     Susan A. Bloomfield · 2020 · Springer eBooks