Lipid metabolism in sarcopenia
Abstract
Sarcopenia is an age-related disease associated with loss of muscle mass and strength. This geriatric syndrome predisposes elderly individuals to a disability, falls, fractures, and death. Fat infiltration in muscle is one of the hallmarks of sarcopenia and aging. Alterations in fatty acid (FA) metabolism are evident in aging, type 2 diabetes, and obesity, with the accumulation of lipids inside muscle cells contributing to muscle insulin resistance and ceramide accumulation. These lipids include diacylglycerol, lipid droplets, intramyocellular lipids, intramuscular triglycerides, and polyunsaturated fatty acids (PUFAs). In this review, we examine the regulation of lipid metabolism in skeletal muscle, including lipid metabolization and storage, intervention, and the types of lipases expressed in skeletal muscle responsible for the breakdown of adipose triglyceride fats. In addition, we address the role of FAs in sarcopenia and the potential benefits of PUFAs.
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Compared with healthy older adults, frail, mobility-impaired and high fall-risk older adults with reduced muscle performance have greater intramyocellular lipids.
“Compared to healthy older adults, studies report greater IMCLs in frail, mobility-impaired and high fall-risk older adults with reduced muscle performance, who are at increased risk of death and disability ([63, 70, 71].”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [71]
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References 83 · Cited by 140
- Authors
- Al Saedi, A., Debruin, D. A., Hayes, A., & Hamrick, M.
- Affiliations
- The University of Melbourne (AU)
- Augusta University (US)
- Venue
- Bone
- Publisher
- Elsevier BV
- Published
- 2022-11
- Volume
- 164
- Pages
- 116539
- ISSN
- 1873-2763 (ISSN-L)
- 8756-3282
- OpenAlex
- W4292985915
- Cited by
- 140
- References
- 83
- Citations by year
- 2026: 29 · 2025: 49 · 2024: 42 · 2023: 19 · 2022: 1
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Bone (publishedVersion)
- PubMed (publishedVersion)
- Victoria University Research Repository (Victoria University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- sarcopenia, lipid metabolism, skeletal muscle, fatty acid metabolism, intramyocellular lipid, intramuscular triglycerides, lipid droplets, diacylglycerol, polyunsaturated fatty acids, muscle insulin resistance, ceramide, lipase, fatty infiltration, aging, type 2 diabetes, obesity
- MeSH terms
- Aged, Ceramides, Diabetes Mellitus, Type 2, Diglycerides, Fatty Acids, Fatty Acids, Unsaturated, Humans, Insulin Resistance, Triglycerides, Muscle, Skeletal, Lipid Metabolism, Sarcopenia
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