Testing for thrombophilia in mesenteric venous thrombosis – Retrospective original study and systematic review
Abstract
The aim was to perform a local study of risk factors and thrombophilia in mesenteric venous thrombosis (MVT), and to review the literature concerning thrombophilia testing in MVT. Patients hospitalized for surgical or medical treatment of MVT at our center 2000-2015. A systematic review of observational studies was performed. In the local study, the most frequently identified risk factor was Factor V Leiden mutation. The systematic review included 14 original studies. The highest pooled percentage of any inherited thrombophilic factor were: Factor V Leiden mutation 9% (CI 2.9-16.1), prothrombin gene mutation 7% (CI 2.7-11.8). The highest pooled percentage of acquired thrombophilic factors were JAK2 V617F mutation 14% (CI -1.9-28.1). The wide range of frequency of inherited and acquired thrombophilic factors in different populations indicates the necessity to relate these factors to background population based data in order to estimate their overrepresentation in MVT. There is a need to develop guidelines for when and how thrombophilia testing should be performed in MVT.
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In a systematic review of 14 studies, a higher prevalence of antithrombin and protein S deficiency was found in patients with mesenteric venous thrombosis compared with the general population and patients with a single venous thromboembolic event.
“In a systematic review of 14 studies, a higher prevalence of prothrombin G20210A gene mutation and antithrombin and protein S deficiency was found compared with the general population and patients with a single venous thromboembolic event (VTE). 213”
In a systematic review of 14 studies, a higher prevalence of prothrombin G20210A gene mutation was found in patients with mesenteric venous thrombosis compared with the general population and patients with a single venous thromboembolic event.
“In a systematic review of 14 studies, a higher prevalence of prothrombin G20210A gene mutation and antithrombin and protein S deficiency was found compared with the general population and patients with a single venous thromboembolic event (VTE). 213”
Cohort studies found a high prevalence of thrombophilia in patients with mesenteric venous thrombosis including over representation of Factor V Leiden and prothrombin G20210A gene mutation, or deficiencies of antithrombin, protein C and protein S, and antiphospholipid antibodies including Lupus anticoagulants.
“Cohort studies found a high prevalence of thrombophilia in patients with MVT including over representation of Factor V Leiden and prothrombin G20210A gene mutation, or deficiencies of antithrombin, protein C and protein S, and antiphospholipid antibodies including Lupus anticoagulants. 213”
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References 91 · Cited by 35
- Authors
- Zarrouk, M., Salim, S., Elf, J., Gottsäter, A., & Acosta, S.
- Affiliations
- Lund University (SE)
- Corresponding author
- Zarrouk, M.
- Venue
- Best Practice & Research Clinical Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 31
- Issue
- 1
- Pages
- 39-48
- ISSN
- 1521-6918 (ISSN-L)
- OpenAlex
- W2568474047
- Cited by
- 35
- References
- 91
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 3
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Health Sciences › Medicine › Surgery › Abdominal vascular conditions and treatments
- Keywords
- mesenteric vein thrombosis, thrombophilia, inherited thrombophilia, acquired thrombophilia, factor V Leiden, prothrombin gene mutation, JAK2 V617F mutation, risk factors
- MeSH terms
- Adult, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Thrombophilia, Genetic Predisposition to Disease, Venous Thrombosis, Mesenteric Ischemia
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