The Dicer-TRBP Interface Structure and Implications for Strand Selection During Microrna Biogenesis
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Changes in Dicer processing sites produce isomiRs with altered thermodynamic end stabilities that reverse strand selection of mammalian miRNAs in vitro.
“Indeed, changes in Dicer processing sites produce isomiRs with altered thermodynamic end stabilities that reverse strand selection of mammalian miRNAs in vitro (Kim et al., 2014; Lee & Doudna, 2012; Wilson & Doudna, 2014; Figure 4d).”
From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Wilson & Doudna, 2014
The available article text (no section or page supplied) discusses a hypothesized role for TRBP in strand selection and experiments disrupting the Dicer–TRBP interaction. It does not address changed Dicer processing sites, isomiR end stabilities, or reversal of strand selection in vitro; searches for those terms found no supporting passage. (LLM, conf=0.73)
Experimental — accuracy not yet measuredIsomiRs resulting from altered Dicer processing sites have been shown to change the thermodynamic properties of mammalian miRNAs, leading to reversed strand selection.
“Indeed, isomiRs resulting from altered Dicer processing sites have been shown to change the thermodynamic properties of mammalian miRNAs, leading to reversed strand selection (Lee & Doudna, 2012; Wilson & Doudna, 2014).”
From microRNA strand selection: Unwinding the rules (2021) · cites this paper as Wilson & Doudna, 2014
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microRNA strand selection: Unwinding the rules
Medley, J. C., Panzade, G., & Zinovyeva, A. Y. (2021) · WIREs RNA · doi:10.1002/wrna.1627 · Cited by 225 · see citing works
- Authors
- Wilson, R. C., & Doudna, J. A.
- Venue
- Biophysical Journal
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 106
- Issue
- 2
- Pages
- 463a
- ISSN
- 0006-3495
- Cited by
- 1
- References
- 0
- Language
- en
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