Brain Extracellular Space: The Final Frontier of Neuroscience

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Items 101–200 of 322

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2. Impedance Rhythms in Human Limbic System
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3. The brain as a “hyper-network”: the key role of neural networks as main producers of the integrated brain actions especially via the “broadcasted” neuroconnectomics
   Luigi F. Agnati, Manuela Marcoli, Guido Maura, Amina S. Woods, Diego Guidolin · 2018 · Journal of Neural Transmission
4. Pharmacokinetic Principles and Their Application to Central Nervous System Tumors
   Joelle P. Straehla, Katherine E. Warren · 2020 · Pharmaceutics
5. Estimates of the permeability of extra-cellular pathways through the astrocyte endfoot sheath
   Timo Koch, Vegard Vinje, Kent‐André Mardal · 2023 · Fluids and Barriers of the CNS
6. Mechanisms of Activation of Brain’s Drainage during Sleep: The Nightlife of Astrocytes
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7. Strategies for enhanced gene delivery to the central nervous system
   Zhenghong Gao · 2024 · Nanoscale Advances
8. A plastic aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neurons
   Laura Kuczynski-Noyau, Sixtine Karmann, Paolo Alberton, Inés Martínez‐Corral, Sreekala S. Nampoothiri, Florent Sauvé, Tori Lhomme, Carmelo Quarta, Suneel Apte, Sébastien G. Bouret et al. · 2024 · Nature Communications
9. Time-Resolved Integrative Optical Imaging of Diffusion during Spreading Depression
   Jan Hrabě, Sabina Hrabětová · 2019 · Biophysical Journal
10. Characterization and Mathematical Modeling of Alginate/Chitosan-Based Nanoparticles Releasing the Chemokine CXCL12 to Attract Glioblastoma Cells
    Suzanne Gascon, Angéla Giraldo Solano, Wiam El Kheir, Hélène Therriault, Pierre Berthelin, Bettina Cattier, Bernard Marcos, Nick Virgilio, Benoît Paquette, Nathalie Faucheux et al. · 2020 · Pharmaceutics
11. T2-fluid-attenuated inversion recovery mismatch sign in lower grade gliomas: correlation with pathological and molecular findings
    Shinji Yamashita, Hideo Takeshima, Yoshihito Kadota, Minako Azuma, Tsuyoshi Fukushima, Natsuki Ogasawara, Tomoki Kawano, Mitsuru Tamura, Jyunichiro Muta, Kiyotaka Saito et al. · 2022 · Brain Tumor Pathology
12. Self-Interference (SELFI) Microscopy for Live Super-Resolution Imaging and Single Particle Tracking in 3D
    Jeanne Linarès-Loyez, Joana S. Ferreira, Olivier Rossier, Brahim Lounis, Grégory Giannone, Laurent Groc, Laurent Cognet, Pierre Bon · 2019 · Frontiers in Physics
13. Anesthesia‐related brain microstructure modulations detected by diffusion magnetic resonance imaging
    Thomas Beck Lindhardt, Christian Stald Skoven, Luca Bordoni, Leif Østergaard, Zhifeng Liang, Brian Hansen · 2023 · NMR in Biomedicine
14. Brain-Penetrating Peptide Shuttles across the Blood–Brain Barrier and Extracellular-like Space
    Xiujuan Peng, Xinquan Liu, Jae You Kim, Alex Nguyen, Jasmim Leal, Debadyuti Ghosh · 2023 · Bioconjugate Chemistry
15. The brain’sglymphatic system:physiological anatomy and clinical perspectives
    Vladimir Nikolaevich Nikolenko, Marine Valikovna Oganesyan, Nikolay N. Yakhno, E. A. Orlov, E. E. Porubayeva, Ekaterina Popova · 2018 · Neurology neuropsychiatry Psychosomatics
16. Spatial Organization and Dynamics of the Extracellular Space in the Mouse Retina
    Sidney P. Kuo, Pei-Pei Chiang, Amy R. Nippert, Eric A. Newman · 2020 · Journal of Neuroscience
17. Attenuation of the extracellular matrix increases the number of synapses but suppresses synaptic plasticity through upregulation of SK channels
    Yulia Dembitskaya, Гаврилов Николай Игоревич, Igor Kraev, Maxim Doronin, Yong Tang, Li Li, Alexey V. Semyanov · 2021 · Cell Calcium
18. Preserving extracellular space for high-quality optical and ultrastructural studies of whole mammalian brains
    Xiaotang Lu, Xiaomeng Han, Yaron Meirovitch, Evelina Sjöstedt, Richard Lee Schalek, Jeff William Lichtman · 2023 · Cell Reports Methods
19. Glucocorticoid Effects on Proteoglycans and Glycosaminoglycans
    Anastasia V. Strokotova, Григорьева Эльвира Витальевна · 2022 · International Journal of Molecular Sciences
20. Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration
    Logsdon, Aric F., Foresi, Brian, Hu, Shannon J., Quah, Emily, Meuret, Cristiana J., Le, Jaden P., Hendrickson, Aarun S., Redford, Ingrid K., Kumar, Asmit, Phan, Bao Anh et al. · 2024 · Journal of Neurochemistry
21. Role of damage-associated molecular patterns in the pathogenesis and therapeutics of traumatic brain injury
    Bowen Sun, Jiarui Zhang, Zhiqiang Li, Jialu Wang, Chuansheng Zhao, Xiaoxue Xu · 2025 · Burns & Trauma
22. Aquaporin‐4 and transient receptor potential vanilloid 4 balance in early postnatal neurodevelopment
    Antonio Cibelli, Maria Grazia Mola, Emanuela Saracino, Barbara Barile, Pasqua Abbrescia, Guido Mogni, David Conover Spray, Eliana Scemes, Andrea Rossi, Diletta Spennato et al. · 2024 · Glia
23. TRPV4 and chloride channels mediate volume sensing in trabecular meshwork cells
    Jackson M. Baumann, Oleg V. Yarishkin, Mónika Lakk, Michael Lucio De Ieso, Christopher N. Rudzitis, Megan N. Kuhn, Yun‐Ting Tseng, William Daniel Stamer, David Križaj · 2024 · American Journal of Physiology-Cell Physiology
24. Is solute movement within the extracellular spaces of brain gray matter brought about primarily by diffusion or flow? A commentary on “Analysis of convective and diffusive transport in the brain interstitium” Fluids and Barriers of the CNS (2019) 16:6 by L. Ray, J.J. Iliff and J.J. Heys
    Stephen B. Hladky, Margery A. Barrand · 2019 · Fluids and Barriers of the CNS
25. Cerebral glymphatic system: Structure, regulation, ageing, and mechanisms of encephalopathy
    Danrui Zhao, Junting Wang, Fengji Zhang, Qing Wang, Mengqing Zang, Haijing Niu, Zhiqian Tong · 2025 · Ageing Research Reviews
26. New Insights into Alzheimer’s Disease: Novel Pathogenesis, Drug Target and Delivery
    Haishu Chen, Jinan Xu, Hanyuan Xu, Tiancheng Luo, Yihao Li, Ke Jiang, Yangping Shentu, Zhiqian Tong · 2023 · Pharmaceutics
27. Integrating Diffusion Tensor Imaging and Neurite Orientation Dispersion and Density Imaging to Improve the Predictive Capabilities of CED Models
    Marco Vidotto, Matteo Pederzani, Antonella Castellano, Valentina Pieri, Andrea Falini, Daniele Dini, Elena De Momi · 2020 · Annals of Biomedical Engineering
28. Unveiling a key role of oxaloacetate-glutamate interaction in regulation of respiration and ROS generation in nonsynaptic brain mitochondria using a kinetic model
    Vitaly A. Selivanov, Olga A. Zagubnaya, Yaroslav R. Nartsissov, Marta Cascante · 2021 · PLoS ONE
29. A stochastic approach to serotonergic fibers in mental disorders
    Skirmantas Janušonis, Nils Detering · 2018 · Biochimie
30. A tridomain model for potassium clearance in optic nerve of Necturus
    Yi Zhu, Shixin Xu, Bob Eisenberg, Huaxiong Huang · 2021 · Biophysical Journal
31. High throughput 3D gel-based neural organotypic model for cellular assays using fluorescence biosensors
    Srikanya Kundu, Molly E. Boutin, Caroline E. Strong, Ty C. Voss, Marc Ferrer · 2022 · Communications Biology
32. Predicting the distribution of serotonergic axons: a supercomputing simulation of reflected fractional Brownian motion in a 3D-mouse brain model
    Skirmantas Janušonis, Justin H. Haiman, Ralf Metzler, Thomas Vojta · 2023 · Frontiers in Computational Neuroscience
33. Gaps in the wall of a perivascular space act as valves to produce a directed flow of cerebrospinal fluid: a hoop-stress model
    Yiming Gan, John Hunter Thomas, Douglas H. Kelley · 2024 · Journal of The Royal Society Interface
34. Effect of Low Intensity Transcranial Ultrasound (LITUS) on Post-traumatic Brain Edema in Rats: Evaluation by Isotropic 3-Dimensional T2 and Multi-TE T2 Weighted MRI
    Tao Zheng, Juan Du, Yi Yuan, Shuo Wu, Yinglan Jin, Qinglei Shi, Xiaohan Wang, Lanxiang Liu · 2020 · Frontiers in Neurology
35. Modulatory Effects of Monoamines and Perineuronal Nets on Output of Cerebellar Purkinje Cells
    Moritoshi Hirono, Fuyuki Karube, Yuchio Yanagawa · 2021 · Frontiers in Neural Circuits
36. Lessons on brain edema in HE: from cellular to animal models and clinical studies
    Katarzyna Pierzchała, Anna Hadjihambi, Jessie Mosso, Rajiv Jalan, Christopher F. Rose, Cristina Cudalbu · 2023 · Metabolic Brain Disease
37. The Impact of Chemical Fixation on the Microanatomy of Mouse Organotypic Hippocampal Slices
    Agata Idziak, V. V. G. Krishna Inavalli, Stéphane Bancelin, Misa Arizono, U. Valentin Nägerl · 2023 · eNeuro
38. Investigation of Antibody Pharmacokinetics in the Brain Following Intra-CNS Administration and Development of PBPK Model to Characterize the Data
    Shengjia Wu, Hsueh-Yuan Chang, Ekram Ahmed Chowdhury, Hsien Wei Huang, Dhaval K. Shah · 2024 · The AAPS Journal
39. Exploring the interstitial system in the brain: the last mile of drug delivery
    Yi Xin Sun, Xinping Sun · 2021 · Reviews in the Neurosciences
40. Sodium Intensity Changes Differ Between Relaxation- and Density-Weighted MRI in Multiple Sclerosis
    Robert Stobbe, Annie Boyd, Penelope S. Smyth, Derek J. Emery, Diana Valdés Cabrera, Christian Beaulieu · 2021 · Frontiers in Neurology
41. Neuraxial drug delivery in pain management: An overview of past, present, and future
    Tony L. Yaksh, Gilson Gonçalves dos Santos, Júlia Borges Paes Lemes, Kauê Franco Malange · 2023 · Best practice & research. Clinical anaesthesiology
42. Characterizing extracellular diffusion properties using diffusion‐weighted MRS of sucrose injected in mouse brain
    Mélissa Vincent, Mylène Gaudin, Covadonga Lucas‐Torres, Alan Wong, Carole Escartin, Julien Valette · 2021 · NMR in Biomedicine
43. Structural Basis of Astrocytic Ca 2 Signals at Tripartite Synapses
    Misa Arizono, Aude Panatier, V. V. G. Krishna Inavalli, Thomas Pfeiffer, Julie Angibaud, Jillian L. Stobart, Luigi Bellocchio, Giovanni Marsicano, Katsuhiko Mikoshiba, Stéphane H.R. Oliet et al. · 2018 · SSRN Electronic Journal
44. Quantitative analysis of molecular transport in the extracellular space using physics-informed neural network
    Jiayi Xie, Hongfeng Li, Shaoyi Su, Jin Cheng, Qingrui Cai, Hanbo Tan, Lingyun Zu, Xiaobo Qu, Hongbin Han · 2024 · Computers in Biology and Medicine
45. Reduction of Dimensionality in Monte Carlo Simulation of Diffusion in Extracellular Space Surrounding Cubic Cells
    Charles Nicholson, Padideh Kamali‐Zare · 2019 · Neurochemical Research
46. The Effect of Thymoquinone on the Characteristics of the Brain Extracellular Space in Transient Middle Cerebral Artery Occlusion Rats
    Chaoxin Fan, Fang Tian, Xin Sheng Zhao, Yi Xin Sun, Xiao-Gai Yang, Hongbin Han, Xiaoping Pu · 2020 · Biological and Pharmaceutical Bulletin
47. The role of glutamate signaling in incentive salience: second‐by‐second glutamate recordings in awake Sprague‐Dawley rats
    Seth R. Batten, François Pomerleau, Jorge E. Quintero, Greg A. Gerhardt, Joshua S. Beckmann · 2018 · Journal of Neurochemistry
48. A critique on the theory of homeostasis.
    L. A. De Luca · 2022 · Physiology and Behavior
49. Calcium Dynamics in Astrocyte-Neuron Communication from Intracellular to Extracellular Signaling
    Agnieszka Nowacka, Maciej Śniegocki, Ewa Ziółkowska · 2025 · Cells
50. Independent actions by HIV-1 Tat and morphine to increase recruitment of monocyte-derived macrophages into the brain in a region-specific manner
    Crystal R. Leibrand, Jason J. Paris, Austin M. Jones, Michael Ohene‐Nyako, Kara M. Rademeyer, Sara R. Nass, Woong‐Ki Kim, Pamela E. Knapp, Kurt F. Hauser, MaryPeace McRae · 2022 · Neuroscience Letters
51. Quantitative Measurement of Brain Extracellular Space with Three-Dimensional Electron Microscopy Imaging
    Xinrui Huang, Kerui Li, Yiqun Liu, Chuqiao Yang, Hongbin Han · 2023 · Sensing and Imaging
52. Immunohistological and Ultrastructural Study of the Inflammatory Response to Perforated Polyimide Cortical Implants: Mechanisms Underlying Deterioration of Electrophysiological Recording Quality
    Shun-Ho Huang, Nava Shmoel, Maciej M. Jankowski, Hadas Erez, Aviv Sharon, Wesal Abu-Salah, Israel Nelken, Aryeh M. Weiss, Micha E. Spira · 2020 · Frontiers in Neuroscience
53. The Influence of Radio-Frequency Transmit Field Inhomogeneities on the Accuracy of G-ratio Weighted Imaging
    Tim Max Emmenegger, Gergely Dávid, Mohammad Ashtarayeh, Francisco J. Fritz, Isabel Ellerbrock, Gunther Helms, Evelyne Balteau, Patrick Freund, Siawoosh Mohammadi · 2021 · Frontiers in Neuroscience
54. A hydrogel-based phantom of the brain tissue aimed at modelling complex metabolic transport processes
    Anastasia S. Vanina, Alexander V. Sychev, Anastasia I. Lavrova, Pavel V. Gavrilov, Polina L. Andropova, Elena V. Grekhnyova, Tatiana N. Kudryavtseva, Eugene B. Postnikov · 2022 · The European Physical Journal Special Topics
55. Advection and diffusion in perivascular and extracellular spaces in the brain
    Yisen Guo, Keelin Quirk, Douglas H. Kelley, John Hunter Thomas · 2025 · Journal of The Royal Society Interface
56. Super-resolution fluorescence imaging of extracellular environments
    Shawn R. Yoshida, Lydia Kisley · 2021 · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy
57. The Emerging Science of Glioception: Contribution of Glia in Sensing, Transduction, Circuit Integration of Interoception
    R. Fabbri, Diletta Spennato, Giorgia Conte, Aikaterini Konstantoulaki, Chiara Lazzarini, Emanuela Saracino, Grazia Paola Nicchia, Antonio Frigeri, Roberto Zamboni, David Conover Spray et al. · 2022 · Pharmacology & Therapeutics
58. Nickel reduces calcium dependent dimerization in neural cadherin
    Matthew P. Dukes, Rhianon K. Rowe, T. Harvey, W. Rangel, Susan Pedigo · 2018 · Metallomics
59. White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age prediction
    Dani Beck, Ann‐Marie G. de Lange, Ivan I. Maximov, Geneviève Richard, Ole A. Andreassen, Jan Egil Nordvik, Lars Tjelta Westlye · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
60. Navigating the Central Nervous System (CNS): A Pharmacokinetic Approach to the Treatment of CNS Tumors, Glioblastoma Multiforme (GBM), in Particular
    Dorota Bartusik‐Aebisher, Jakub Tylutki, Michał Tylutki, Dominika Leś, David Aebisher · 2025 · International Journal of Molecular Sciences
61. Model of glymphatic clearance of aggregating proteins from the brain interstitium
    Saikat Mukherjee, Jeffrey Tithof · 2022 · Physical review. E
62. Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and Release
    Hejian Xiong, Blake A. Wilson, Paul A. Slesinger, Zhenpeng Qin · 2023 · ACS Chemical Neuroscience
63. Mapping Extracellular Space Features of Viral Encephalitis to Evaluate the Proficiency of Anti‐Viral Drugs
    Lei Wang, Hua‐Jie Chen, Zhi‐Gang Wang, Di Ning, Wei Guang Zhao, Virgile Rat, Don C. Lamb, Dai‐Wen Pang, Shu‐Lin Liu · 2024 · Advanced Materials
64. Modeling of brain efflux: Constraints of brain surfaces
    Peter A. R. Bork, Natalie Linea Hauglund, Yuki Mori, Kjeld Møllgård, Poul Georg Hjorth, Maiken Nedergaard · 2024 · Proceedings of the National Academy of Sciences
65. Exploring cell membrane water exchange in aquaporin-4-deficient ischemic mouse brain using diffusion-weighted MRI
    Takuya Urushihata, Hiroyuki Takuwa, Manami Takahashi, Jeff Kershaw, Yasuhiko Tachibana, Nobuhiro Nitta, Sayaka Shibata, Masato Yasui, Makoto Higuchi, Takayuki Obata · 2021 · European Radiology Experimental
66. Modeling Blood–Brain Barrier Permeability to Solutes and Drugs In Vivo
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67. Advancement in modulation of brain extracellular space and unlocking its potential for intervention of neurological diseases
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68. Live STED imaging of functional neuroanatomy
    Misa Arizono, Agata Idziak, U. Valentin Nägerl · 2025 · Nature Protocols
69. Neuroglia and extracellular matrix molecules
    Egor Dzyubenko, Dirk Matthias Hermann · 2025 · Handbook of clinical neurology
70. Sheet and void porous media models for brain interstitial space
    Charles Nicholson · 2023 · Journal of The Royal Society Interface
71. Novel immunotherapeutic approaches to cancer: Voltage-gated sodium channel expression in immune cells and tumors
    Mustafa B.A. Djamgoz, Laetitia Firmenich · 2021 · Elsevier eBooks
72. Location of dopamine in lipid bilayers and its relevance to neuromodulator function
    Azam Shafieenezhad, Saheli Mitra, Stephen R. Wassall, Stephanie Tristram‐Nagle, John F. Nagle, Horia I. Petrache · 2023 · Biophysical Journal
73. FCNN-based axon segmentation for convection-enhanced delivery optimization
    Marco Vidotto, Elena De Momi, Michele Gazzara, Leonardo S. Mattos, Giancarlo Ferrigno, Sara Moccia · 2019 · International Journal of Computer Assisted Radiology and Surgery
74. Imaging probes for the detection of brain microenvironment
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75. Contrast Agent Clearance Dynamics and Diffusion in the Mouse Brain After Ventricular Administration
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76. Brain fluid physiology in ischaemic stroke; more than just oedema
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77. Toward dynamic, anisotropic, high-resolution, and functional measurement in the brain extracellular space
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78. Wettability effect on hydraulic permeability of brain white matter
    Lijun Su, Jie-Chao Lei, Zhenxing Li, Chiyuan Ma, Shaobao Liu · 2024 · Acta Mechanica Sinica
79. Do enlarged white matter perivascular spaces reflect brain clearance dysfunction? Insights from intrathecal contrast-enhanced MRI
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80. Measuring cerebral enzymatic activity, brain pH and extracranial muscle metabolism with hyperpolarized 13 C‐pyruvate
    Alixander S. Khan, Mary Anne McLean, Joshua Daniel Kaggie, Ines Horvat‐Menih, Tomasz Matys, Rolf F. Schulte, Matthew J. Locke, Ashley Grimmer, Pascal Wodtke, Elizabeth Latimer et al. · 2024 · NMR in Biomedicine
81. Numerical Simulations Reveal Complementary Function of Blood-Brain Barrier and Glymphatic Transport in the Brain
    Reza Yousofvand, Jeffrey Tithof · 2025 · Physical Review Letters
82. Bridging macroscopic and microscopic modeling of electric field by brain stimulation
    Boshuo Wang, Aman S. Aberra · 2025 · Brain stimulation
83. Diffusion MRI derived free-water imaging measures in patients with schizophrenia and their non-psychotic siblings
    Xiao Chang, René C.W. Mandl, Ofer Pasternak, Rachel M. Brouwer, Wiepke Cahn, Guusje Collin · 2021 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
84. Learning from the brain’s architecture: bioinspired strategies towards implantable neural interfaces
    Nicholas J. Rommelfanger, Carl H. C. Keck, Yihang Chen, Guosong Hong · 2021 · Current Opinion in Biotechnology
85. Exploring the Dynamics of Brain Extracellular Space
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86. The Impact of Anomalous Diffusion on Action Potentials in Myelinated Neurons
    Corina Stefania Drapaca · 2021 · Fractal and Fractional
87. Blind zones in radiating dispersion at high Péclet number driven by non-Newtonian fluids in porous media
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88. Fluid flow and amyloid transport and aggregation in the brain interstitial space
    Antonio Iorio, Simone Melchionna, Philippe Derreumaux, Fabio Sterpone · 2024 · PNAS Nexus
89. Improving the Detection of Analyte Degeneracies in Untargeted Liquid Chromatography-Tandem Mass Spectrometry Data
    Caitlin N. Cain, Cheng-Hua Ma, Pavlo Popov, Robert T. Kennedy · 2025 · Analytical Chemistry
90. Smart Organic–Inorganic Copolymer Nanoparticles Distinguish Between Microglia and Cancer Cells for Synergistic Immunotherapy in Glioma
    Shiming Zhang, Kun Shang, Lidong Gong, Qian Xie, Jianfei Sun, Meng Michelle Xu, Xunbin Wei, Zhaoheng Xie, Xinyu Liu, Hao Tang et al. · 2025 · Advanced Science
91. Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof‐of‐concept clinical study
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92. A Non-local Model of the Propagation of Action Potentials in Myelinated Neurons
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93. Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection
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94. Leveraging Biomaterial Platforms to Study Aging-Related Neural and Muscular Degeneration
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95. Effects of cell packing on chemoattractant distribution within a tissue
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96. Diffusion assessment through image processing: beyond the point-source paradigm
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97. Screening and bioinformatics analysis of key biomarkers in acute myocardial infarction
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98. Cellular mechanisms mediating activity‐dependent extracellular space shrinkage in the retina
    Pei‐Pei Chiang, Sidney P. Kuo, Eric A. Newman · 2022 · Glia
99. Dexamethasone effects on the expression and content of glycosylated components of mouse brain tissue
    Stanislav D. Aladev, Dmitry K. Sokolov, Anastasia V. Strokotova, Galina M. Kazanskaya, А. М. Волков, Maxim O. Politko, A. I. Shahmuradova, Evgeniy E. Kliver, Alexandra Y. Tsidulko, Svetlana V. Aidagulova et al. · 2023 · Advances in molecular oncology
100. Cerebrospinal fluid solute transport associated with sensorimotor brain activity in rodents
     Evgenii Kim, Jared Van Reet, Seung‐Schik Yoo · 2023 · Scientific Reports