Pathogenesis of endometriosis
Abstract
Many women harbour spots of peritoneal endometriosis without having any symptoms; this is referred to as the phenomenon endometriosis. Some of these women go on to develop symptomatic endometriosis. Although we know the factors potentially involved in the aetiology and pathogenesis of endometriosis, the exact mechanism by which the phenomenon endometriosis develops into the disease endometriosis, with its associated signs and symptoms, remain obscure. The widely accepted theory is Sampson's transplantation theory. Recent findings indicate that certain properties of the endometrium, and the influence of the local environment, are crucial in the development of endometriosis. Early endometriosis lesion formation is described in detail, as this seems to be a key process in the development of peritoneal endometriosis.
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Retrograde transport of menstrual blood occurs in nearly 90% of women of childbearing age.
“It has still not been possible to fully explain why the retrograde transport of menstrual blood, which occurs in nearly 90% of women of childbearing age, only leads to the survival of endometrial tissue outside the uterine cavity in a minority of women [7].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [7]
It has not been possible to fully explain why retrograde transport of menstrual blood, which occurs in nearly 90% of women of childbearing age, only leads to survival of endometrial tissue outside the uterine cavity in a minority of women.
“It has still not been possible to fully explain why the retrograde transport of menstrual blood, which occurs in nearly 90% of women of childbearing age, only leads to the survival of endometrial tissue outside the uterine cavity in a minority of women [7].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [7]
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References 77 · Cited by 138
- Authors
- Nap, A. W., Groothuis, P. G., Demir, A. Y., Evers, J. L. H., & Dunselman, G. A. J.
- Affiliations
- Maastricht University Medical Centre (NL)
- University Medical Center Utrecht (NL)
- Corresponding author
- Dunselman, Gerard A.J
- Venue
- Best Practice & Research Clinical Obstetrics & Gynaecology
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 18
- Issue
- 2
- Pages
- 233-244
- ISSN
- 1521-6934 (ISSN-L)
- OpenAlex
- W2052325118
- Cited by
- 138
- References
- 77
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 7 · 2012: 14
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, pathogenesis, peritoneal endometriosis, endometrium, lesion formation, etiology, local microenvironment
- MeSH terms
- Endometriosis, Endometrium, Estrogens, Female, Humans, Menstruation, Neovascularization, Pathologic, Peritoneal Diseases, Matrix Metalloproteinases
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