Enhanced visuomotor associative learning following stimulation of α2A-adrenoceptors in the ventral prefrontal cortex in monkeys
Abstract
The present study investigated the effect of locally infused guanfacine, an alpha2A-adrenergic agonist, into the ventral prefrontal cortex (PFv) on visuomotor associative learning. Two monkeys were well trained on a two-problem visuomotor associative task: the monkeys performed movement A if presented with a circle pattern, or movement B if presented with a triangle pattern. For learning of new visuomotor associations, the monkeys were presented with a new set of four patterns in each and every daily session, two of which instructed movement A and the other two movement B. Bilaterally infused guanfacine (2.5 microg/microl; 3 microl on each side) improved the monkeys' ability to learn new visuomotor associations: trials and errors to learning criterion of 90% correct decreased significantly. The monkeys showed an enhanced capability to use win-stay/lose-shift strategy on 'repeat trials' and change-stay/change-shift strategy on 'change trials.' The present results indicate that alpha2A-adrenoceptor in the PFv is involved in regulating visuomotor associative learning.
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Direct infusions of guanfacine into lateral PFC improved working memory and associative learning in monkeys.
“For example, direct infusions of guanfacine into the lateral PFC improved performance of working memory and associative learning tasks in monkeys (Mao et al., 1999, Wang et al., 2004).”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Wang et al., 2004
Either systemic or direct infusion of guanfacine into ventral PFC improves performance of monkeys performing paired associates learning task.
“Either systemic or direct infusion of guanfacine into the ventral PFC improved the performance of monkeys performing a paired associates learning task”
From Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species (2020) · cites this paper as Wang et al., 2004
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References 34 · Cited by 31
- Authors
- Wang, M., Tang, Z.-X., & Li, B.-M.
- Affiliations
- Fudan University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Li, Bao-Ming
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 1024
- Issue
- 1-2
- Pages
- 176-182
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1987257689
- Cited by
- 31
- References
- 34
- Citations by year
- 2023: 1 · 2021: 3 · 2020: 1 · 2015: 3 · 2014: 3 · 2012: 2
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- alpha2A-adrenoceptor, ventral prefrontal cortex, guanfacine, local infusion, monkeys, win-stay lose-shift strategy, pattern recognition
- MeSH terms
- Animals, Association Learning, Macaca mulatta, Male, Psychomotor Performance, Guanfacine, Prefrontal Cortex, Receptors, Adrenergic, alpha-2, Adrenergic alpha-2 Receptor Agonists
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