Expression of PINK1 mRNA in human and rodent brain and in Parkinson's disease
Abstract
Mutations in PINK1 (PTEN-induced putative kinase 1) are causal for early onset recessive parkinsonism in humans, characterized by damage to the nigrostriatal system. In situ hybridization studies in rodent brains have suggested a predominantly neuronal expression of PINK1 mRNA but immunocytochemistry of human brain tissue has shown PINK1-like immunoreactivity in both neurons and glia. In this study, we assessed the comparative distribution of PINK1 mRNA in human, rat and mouse brain. We observe that in humans PINK1 message is expressed in neurons with very little to no signal in glia and confirms similar findings in rodent tissue. Highest levels of expression were observed in hippocampus, substantia nigra and cerebellar Purkinje cells. We also show that PINK1 mRNA expression is similar in nigral neurons from neurologically normal controls and sporadic Parkinson's disease cases.
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PINK1 is expressed ubiquitously in neurons throughout the human brain.
“PINK1 is expressed ubiquitously in neurons throughout the human brain [59, 60].”
From miR-27a and miR-27b regulate autophagic clearance of damaged mitochondria by targeting PTEN-induced putative kinase 1 (PINK1) (2016) · cites this paper as [59]
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References 25 · Cited by 59
- Authors
- Blackinton, J. G., Anvret, A., Beilina, A., Olson, L., Cookson, M. R., & Galter, D.
- Affiliations
- National Institutes of Health (US)
- Karolinska Institutet (SE)
- Corresponding author
- Galter, Dagmar
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 1184
- Pages
- 10-16
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2036315090
- Cited by
- 59
- References
- 25
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 4 · 2014: 5 · 2013: 7 · 2012: 3
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (MH.NS 31862)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- PINK1, Parkinson's disease, nigrostriatal pathway, substantia nigra, hippocampus, Purkinje cells, neuronal expression, glial expression
- MeSH terms
- PTEN-Induced Putative Kinase, Animals, Brain, Humans, Neurons, Parkinson Disease, Protein Kinases, RNA, Messenger, Gene Expression, In Situ Hybridization, Mice, Rats
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