Region-specific susceptibilities to cuprizone-induced lesions in the mouse forebrain: Implications for the pathophysiology of schizophrenia

Yang, Hong-Ju; Wang, Haitao; Zhang, Yanbo; Xiao, Lan; Clough, Richard W.; Browning, Ronald; Li, Xin-Min; Xu, Haiyun

doi:10.1016/j.brainres.2009.03.011

Region-specific susceptibilities to cuprizone-induced lesions in the mouse forebrain: Implications for the pathophysiology of schizophrenia

Cuprizone (CPZ) is a neurotoxic agent acting as a copper chelator. In our recent study, C57BL/6 mice given dietary CPZ (0.2%) showed impairments in spatial working memory, social interaction, and prepulse inhibition. These abnormalities are reminiscent of certain schizophrenia symptoms and are no…