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Cited by 125Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal PhysiologyStress Responses and Cortisol

Molecular and genetic substrates linking stress and addiction

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Briand, Lisa A., Blendy, Julie A.·2010·Brain Research
DOI 10.1016/j.brainres.2009.11.002PMC PMC2819611
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Abstract

Drug addiction is one of the top three health concerns in the United States in terms of economic and health care costs. Despite this, there are very few effective treatment options available. Therefore, understanding the causes and molecular mechanisms underlying the transition from casual drug use to compulsive drug addiction could aid in the development of treatment options. Studies in humans and animal models indicate that stress can lead to both vulnerability to develop addiction, and increased drug taking and relapse in addicted individuals. Exposure to stress or drugs of abuse results in long-term adaptations in the brain that are likely to involve persistent alterations in gene expression or activation of transcription factors, such as the cAMP Response Element Binding (CREB) protein. The signaling pathways controlled by CREB have been strongly implicated in drug addiction and stress. Many potential CREB target genes have been identified based on the presence of a CRE element in promoter DNA sequences. These include, but are not limited to CRF, BDNF, and dynorphin. These genes have been associated with initiation or reinstatement of drug reward and are altered in one direction or the other following stress. While many reviews have examined the interactions between stress and addiction, the goal of this review was to focus on specific molecules that play key roles in both stress and addiction and are therefore posed to mediate the interaction between the two. Focus on these molecules could provide us with new targets for pharmacological treatments for addiction.

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Authors
Briand, L. A., & Blendy, J. A.
Affiliations
University of Pennsylvania (US)
Corresponding author
Blendy, Julie A.
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
2010-02
Volume
1314
Pages
219-234
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2009.11.002
PMC
PMC2819611
OpenAlex
W2032463884
Cited by
125
References
285
Citations by year
2025: 2 · 2024: 4 · 2023: 4 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 11 · 2015: 5 · 2014: 9 · 2013: 12 · 2012: 18
FWCI
1.10
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (DA-11649)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
drug addiction, stress, CREB, CRF, brain-derived neurotrophic factor, dynorphin, drug relapse, drug reward, gene expression, addiction treatment targets
MeSH terms
Animals, Brain Chemistry, Corticotropin-Releasing Hormone, Dynorphins, Gene Expression Regulation, Humans, Neuronal Plasticity, Stress, Psychological, Cyclic AMP Response Element-Binding Protein, Brain-Derived Neurotrophic Factor, Substance-Related Disorders

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