miR-29c regulates BACE1 protein expression
Abstract
Recently, BACE1 expression was shown to be regulated by microRNAs, small endogenous RNA molecules that regulate protein expression through sequence-specific interaction with messenger RNA. Here, we showed that microRNA-29c (miR-29c), a miRNA that is enriched in the brain and highly expressed in the APPswe/PSΔE9 mouse lowers BACE1 protein in vitro and in transgenic miR-29c mice. In silico analysis identified two putative target sites in the BACE1 mRNA for the miR-29c family. We chose SH-SY5Y, HEK-293T cell lines and miR-29c transgenic mice for these studies to validate our hypothesis. Significantly, over-expression of miR-29c in SH-SY5Y, HEK-293T cell lines and miR-29c transgenic mice downregulated BACE1 protein levels. Our findings suggest that miR-29c may be an endogenous regulator of BACE1 protein expression.
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Several miRNAs have been identified as regulators of BACE1 expression.
“So far, several miRNAs have been identified as regulators of BACE1 expression (Hebert et al. 2008, Zong et al. 2011, Zhu et al. 2012, Fang et al. 2012, Wang et al. 2008b, Boissonneault et al. 2009, Long et al. 2014), suggesting that an extensive network of multiple miRNAs may regulate BACE1 expression in a coordinated manner.”
From miR‐186 is decreased in aged brain and suppresses <scp>BACE</scp>1 expression (2016) · cites this paper as Zong et al. 2011
An extensive network of multiple miRNAs may regulate BACE1 expression in a coordinated manner.
“So far, several miRNAs have been identified as regulators of BACE1 expression (Hebert et al. 2008, Zong et al. 2011, Zhu et al. 2012, Fang et al. 2012, Wang et al. 2008b, Boissonneault et al. 2009, Long et al. 2014), suggesting that an extensive network of multiple miRNAs may regulate BACE1 expression in a coordinated manner.”
From miR‐186 is decreased in aged brain and suppresses <scp>BACE</scp>1 expression (2016) · cites this paper as Zong et al. 2011
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References 22 · Cited by 117
- Authors
- Zong, Y., Wang, H., Dong, W., Quan, X., Zhu, H., Xu, Y., Huang, L., Ma, C., & Qin, C.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Qin, Chuan
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 1395
- Pages
- 108-115
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2012620585
- Cited by
- 117
- References
- 22
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 4 · 2017: 9 · 2016: 7 · 2015: 12 · 2014: 12 · 2013: 10 · 2012: 6
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Update notices
- erratum (2024-10-01)
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- miR-29c, BACE1, microRNA regulation, protein expression, Alzheimer's disease, microRNA binding sites, transgenic mice, SH-SY5Y cells, HEK293T cells
- MeSH terms
- Animals, Gene Expression Regulation, Humans, Mice, Inbred C57BL, Mice, Transgenic, Mutation, Down-Regulation, Aspartic Acid Endopeptidases, Transgenes, MicroRNAs, Cell Line, Tumor, Mice, Amyloid Precursor Protein Secretases, HEK293 Cells
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