Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury

Pajoohesh-Ganji, Ahdeah; Burns, Mark P.; Pal-Ghosh, Sonali; Tadvalkar, Gauri; Hokenbury, Nicole G.; Stepp, Mary Ann; Faden, Alan I.

doi:10.1016/j.brainres.2014.02.049

Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury

Amyloid-β (Aβ) is produced through the enzymatic cleavage of amyloid precursor protein (APP) by β (Bace1) and γ -secretases. The accumulation and aggregation of Aβ as amyloid plaques is the hallmark pathology of Alzheimer’s disease and has been found in other neurological disorders, such as traum…