Inflammatory cytokine-associated depression
Open accessAbstract
Inflammatory cytokines can sometimes trigger depression in humans, are often associated with depression, and can elicit some behaviors in animals that are homologous to major depression. Moreover, these cytokines can affect monoaminergic and glutamatergic systems, supporting an overlapping pathoetiology with major depression. This suggests that there could be a specific major depression subtype, inflammatory cytokine-associated depression (ICAD), which may require different therapeutic approaches. However, most people do not develop depression, even when exposed to sustained elevations in inflammatory cytokines. Thus several vulnerabilities and sources of resilience to inflammation-associated depression have been identified. These range from genetic differences in neurotrophic and serotonergic systems to sleep quality and omega-3 fatty acid levels. Replicating these sources of resilience as treatments could be one approach for preventing "ICAD". This article is part of a Special Issue entitled SI: Neuroimmunology in Health And Disease.
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Fat cells release MCP-1, which leads to macrophage infiltration and more inflammation.
“Fat cells also release monocyte chemoattractant protein-1 (MCP-1), which leads to macrophage infiltration and more inflammation.203”
From Ketamine as an antidepressant: Overview of its mechanisms of action and potential predictive biomarkers (2020) · cites this paper as [203]
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- Authors
- Lotrich, F. E.
- Affiliations
- University of Pittsburgh Medical Center (US)
- Corresponding author
- Lotrich, Francis E.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 1617
- Pages
- 113-125
- ISSN
- 0006-8993 (ISSN-L)
- PMC
- PMC4284141
- OpenAlex
- W2079657721
- Cited by
- 183
- References
- 296
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 21 · 2023: 21 · 2022: 18 · 2021: 15 · 2020: 24 · 2019: 18 · 2018: 9 · 2017: 10 · 2016: 11 · 2015: 8 · 2014: 6
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIMH (MH090250)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- inflammatory cytokines, major depressive disorder, neuroinflammation, monoaminergic systems, glutamatergic system, genetic susceptibility, neurotrophic factors, serotonergic system, sleep quality, omega-3 fatty acids, neuroimmunology, animal models of depression
- MeSH terms
- Animals, Brain, Depressive Disorder, Major, Major Depressive Disorder, Glutamates, Humans, Inflammation, Nerve Growth Factors, Biogenic Monoamines, Cytokines, Inflammation Mediators
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