Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models

Su, Chunhe; Yang, Xiaopeng; Lou, Jiyu

doi:10.1016/j.brainres.2016.05.011

Geniposide reduces α-synuclein by blocking microRNA-21/lysosome-associated membrane protein 2A interaction in Parkinson disease models

Objective This study aimed to explore whether the regulatory effect of miR-21 on α-synuclein expression in neurons is a potential mechanism by which geniopside (GP) protects the central nervous system from Parkinson disease (PD). Methods The human neuroblastoma cell line SH-SY5Y was induced to…