miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis

Ge, Xintong; Huang, Shan; Gao, Huabin; Han, Zhaoli; Chen, Fanglian; Zhang, Shishuang; Wang, Zengguang; Kang, Chunsheng; Jiang, Rongcai; Yue, Shuyuan; Lei, Ping; Zhang, Jianning

doi:10.1016/j.brainres.2016.07.015

miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis

Our recent researches have identified increased expression of miR-21-5p in rats brain following traumatic brain injury (TBI), which protected against blood-brain barrier (BBB) damage. To further study the mechanism underlying the role of miR-21-5p on alleviating BBB damage after TBI, we performed…