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Cited by 509

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases

Open access
Cartier, Laetitia, Hartley, Oliver, Dubois-Dauphin, Michel, Krause, Karl-Heinz·2005·Brain Research Reviews
DOI 10.1016/j.brainresrev.2004.07.021
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Abstract

Chemokines were originally described as chemotactic cytokines involved in leukocyte trafficking. Research over the last decade, however, has shown that chemokine receptors are not restricted to leukocytes. In the brain, chemokine receptors are not only found in microglia (a brain macrophage), but also in astrocytes, oligodendrocytes and neurons. In this review, we describe the spatial and cellular distribution of chemokine receptors in the brain, distinguishing between constitutively and inducibly expressed receptors. We then discuss possible physiological functions, including neuronal migration, cell proliferation and synaptic activity. Evidence is emerging that chemokine receptors are also involved in neuronal death and hence neurodegenerative diseases. Chemokines may induce neuronal death either indirectly (e.g. through activation of microglia killing mechanisms) or directly through activation of neuronal chemokine receptors. Disease processes in which chemokines and their receptors are likely to be involved include multiple sclerosis (MS), Alzheimer's disease (AD), HIV-associated dementia (HAD) and cerebral ischemic disease. The study of chemokines and their receptors in the central nervous system (CNS) is not only relevant for the understanding of brain physiology and pathophysiology, but may also lead to the development of targeted treatments for neurodegenerative diseases.

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Metadata

Authors
Cartier, L., Hartley, O., Dubois-Dauphin, M., & Krause, K.-H.
Venue
Brain Research Reviews
Publisher
Elsevier BV
Published
2005-02
Volume
48
Issue
1
Pages
16-42
ISSN
0165-0173 (ISSN-L)
DOI
10.1016/j.brainresrev.2004.07.021
OpenAlex
W1974955493
Cited by
509
References
14
FWCI
10.14
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. https://app.cochat.ai/papers/10.1016/j.brainresrev.2004.07.021
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Cartier, L., Hartley, O., Dubois-Dauphin, M., & Krause, K.-H. (2005). Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Research Reviews. https://doi.org/10.1016/j.brainresrev.2004.07.021

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.