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Cited by 308Heart Rate Variability and Autonomic ControlVagus Nerve Stimulation ResearchNeuroscience of respiration and sleep

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

The yin and yang of cardiac autonomic control: Vago-sympathetic interactions revisited

Paton, J.F.R., Boscan, P., Pickering, A.E., Nalivaiko, E.·2005·Brain Research Reviews
DOI 10.1016/j.brainresrev.2005.02.005
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Abstract

We review the pattern of activity in the parasympathetic and sympathetic nerves innervating the heart. Unlike the conventional textbook picture of reciprocal control of cardiac vagal and sympathetic nervous activity, as seen during a baroreceptor reflex, many other reflexes involve simultaneous co-activation of both autonomic limbs. Indeed, even at 'rest', the heart receives tonic drives from both sympathetic and parasympathetic cardiac nerves. Autonomic co-activation occurs during peripheral chemoreceptor, diving, oculocardiac, somatic nociceptor reflex responses as well as being evoked from structures within the brain. It is suggested that simultaneous co-activation may lead to a more efficient cardiac function giving greater cardiac output than activation of the sympathetic limb alone; this permits both a longer time for ventricular filling and a stronger contraction of the myocardium. This may be important when pumping blood into a constricted vascular tree such as is the case during the diving response. We discuss that in some instances, high drive to the heart from both autonomic limbs may also be arrhythmogenic.

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Crossref · 10.1016/j.brainresrev.2005.02.005

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69 of 69 references verified0 citation errors · 0 not checkable

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Citations

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Research works printed but not linked: 3

  1. Angell-James, 1969, Nasal reflexes, Proc. R. Soc. Med., 62, 1287
  2. Dutschmann, 2000, Is the diving reflex present in the working heart–brainstem preparation (WHBP) of the rat?, J. Physiol., 523P, 254P
  3. Lundberg, 1979, Enkephalin, substance P, VIP, somatostatin, gastrin/CCK and neurotensin in peripheral neurones, Acta Physiol. Scand., 469, S14

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Metadata

Authors
Paton, J. F. R., Boscan, P., Pickering, A. E., & Nalivaiko, E.
Affiliations
  • University of Bristol (GB)
  • Veterinary Medical Teaching Hospital (US)
  • Flinders University (AU)
Corresponding author
Nalivaiko, E.
ORCID
Venue
Brain Research Reviews
Publisher
Elsevier BV
Published
2005-11
Volume
49
Issue
3
Pages
555-565
ISSN
0165-0173 (ISSN-L)
DOI
10.1016/j.brainresrev.2005.02.005
OpenAlex
W1977962340
Cited by
308
References
69
Citations by year
2026: 3 · 2025: 9 · 2024: 16 · 2023: 14 · 2022: 13 · 2021: 17 · 2020: 18 · 2019: 22 · 2018: 23 · 2017: 16 · 2016: 11 · 2015: 19 · 2014: 15 · 2013: 31 · 2012: 23
FWCI
1.78
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Explore Bristol Research (submittedVersion)
Funders
  • British Heart Foundation
  • University of Bristol
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Keywords
cardiac autonomic control, baroreflex, chemoreceptor reflex, diving reflex, oculocardiac reflex, nociceptive reflex, cardiac output, ventricular filling, cardiac contraction, arrhythmogenesis, autonomic reflexes
MeSH terms
Animals, Autonomic Nervous System, Heart, Humans, Parasympathetic Nervous System, Sympathetic Nervous System, Tachycardia, Vagus Nerve, Yin-Yang

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