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Cited by 80Pain Mechanisms and TreatmentsIon Channels and ReceptorsGastrointestinal motility and disorders

Development, plasticity and modulation of visceral afferents

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Christianson, Julie A., Bielefeldt, Klaus, Altier, Christophe, Cenac, Nicolas, Davis, Brian M., Gebhart, Gerald F., High, Karin W., Kollarik, Marian +3 more·2009·Brain Research Reviews
DOI 10.1016/j.brainresrev.2008.12.004PMC PMC2841801
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Abstract

Visceral pain is the most common reason for doctor visits in the US. Like somatic pain, virtually all visceral pain sensations begin with the activation of primary sensory neurons innervating the viscera and/or the blood vessels associated with these structures. Visceral afferents also play a central role in tissue homeostasis. Recent studies show that in addition to monitoring the state of the viscera, they perform efferent functions through the release of small molecules (e.g. peptides like CGRP) that can drive inflammation, thereby contributing to the development of visceral pathologies (e.g. diabetes Razavi, R., Chan, Y., Afifiyan, F.N., Liu, X.J., Wan, X., Yantha, J., Tsui, H., Tang, L., Tsai, S., Santamaria, P., Driver, J.P., Serreze, D., Salter, M.W., Dosch, H.M., 2006. TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes, Cell 127 1123-1135). Visceral afferents are heterogeneous with respect to their anatomy, neurochemistry and function. They are also highly plastic in that their cellular environment continuously influences their response properties. This plasticity makes them susceptible to long-term changes that may contribute significantly to the development of persistent pain states such as those associated with irritable bowel syndrome, pancreatitis, and visceral cancers. This review examines recent insights into visceral afferent anatomy and neurochemistry and how neonatal insults can affect the function of these neurons in the adult. New approaches to the treatment of visceral pain, which focus on primary afferents, will also be discussed.

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  • The sensory tone of the vagal/pelvic and splanchnic signaling pathways is not mutually exclusive, and physiological events relating to gut status can also be transmitted through spinal splanchnic innervation via the NTS of the brainstem to higher centers.

    “However, it must be stated that the sensory tone of these signaling pathways is not mutually exclusive, and that physiological events relating to the status of the gut including distension, motility, inflammation, pain, pH change, cellular damage or temperature (Brookes et al., 2016) can also be transmitted through spinal splanchnic innervation via NTS of the brainstem (Christianson et al., 2009;R”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Christianson et al., 2009

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References 143 · Cited by 80

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Authors
Christianson, J. A., Bielefeldt, K., Altier, C., Cenac, N., Davis, B. M., Gebhart, G. F., High, K. W., Kollarik, M., Randich, A., Undem, B., & Vergnolle, N.
Affiliations
  • University of Pittsburgh (US)
  • University of Calgary (CA)
  • University of Alabama at Birmingham (US)
  • University of Kentucky (US)
Corresponding author
Davis, Brian M.
ORCID
Venue
Brain Research Reviews
Publisher
Elsevier BV
Published
2009-04
Volume
60
Issue
1
Pages
171-186
ISSN
0165-0173 (ISSN-L)
DOI
10.1016/j.brainresrev.2008.12.004
PMC
PMC2841801
OpenAlex
W2098074651
Cited by
80
References
143
Citations by year
2026: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 3 · 2015: 8 · 2014: 10 · 2013: 8 · 2012: 6
FWCI
0.62
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R01NS050758)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
visceral afferents, visceral pain, primary sensory neurons, neuroplasticity, calcitonin gene-related peptide, inflammation, irritable bowel syndrome, pancreatitis
MeSH terms
Animals, Humans, Inflammation, Neuronal Plasticity, Neuropeptides, Nociceptors, Pain, Sensory Receptor Cells, Viscera, Visceral Afferents, TRPV Cation Channels

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