The DOI matches its Crossref record; 227 of the 229 references it cites were found in a registry or an index.
A behavioural neuroscience perspective on the aetiology and treatment of anxiety disorders
Abstract
Over the past decades, behaviour and cognitive psychology have produced fruitful and mutually converging theories from which hypotheses could be derived on the nature and origin of fear and anxiety disorders. Notwithstanding the emergence of effective treatments, there are still many questions that remain to be answered. Here, I will argue that the burgeoning field of behavioural neuroscience may advance our understanding of fear, anxiety disorders and its treatments. Decades of fear-conditioning research across species have begun to elucidate the neurobiological mechanisms underlying associative fear learning and memory. The fear-conditioning paradigm provides a well-controlled and fine-grained research platform to examine these processes. Although the traditional fear conditioning paradigm was originally designed to unveil general principles of fear (un)learning, it is well-suited to understand the transition from normal fear to pathological fear and the mechanisms of change. This paper presents 1) a selection of fear conditioning studies on the generalization and persistence of associative fear memory as intermediate phenotypes of fear and anxiety disorders, and 2) insights from neuroscience on the malleability of fear memory with the potential to provide a long-term cure for anxiety and related disorders.
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“Fear conditioning has become widely regarded as a valid experimental model of clinical anxiety disorders and thus it is hoped that further advances in the scientific study of fear-conditioning processes will yield translational benefits in the form of optimized pathophysiological models of these common mental health disorders.2”
From Neural signatures of human fear conditioning: an updated and extended meta-analysis of fMRI studies (2016) · cites this paper as [2]
Citations
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Research on the neural circuits and treatment of anxiety
Cai, Y. (2023) · Theoretical and Natural Science · doi:10.54254/2753-8818/24/20231122
Meister, L., Rosi‐Andersen, A., Bavato, F., Xia, Y., Bach, D. R., & Kleim, B. (2026) · Translational Psychiatry · doi:10.1038/s41398-025-03657-0
Coulombe-Lévêque, A., Bonin, R. P., & Léonard, G. (2026) · Pain · doi:10.1097/j.pain.0000000000004013
Metadata
- Authors
- Kindt, M.
- Affiliations
- University of Amsterdam (NL)
- Corresponding author
- Kindt, Merel
- ORCID
- Kindt, Merel
- Venue
- Behaviour Research and Therapy
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 62
- Pages
- 24-36
- ISSN
- 0005-7967 (ISSN-L)
- OpenAlex
- W2015776484
- Cited by
- 103
- References
- 229
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 14 · 2021: 6 · 2020: 6 · 2019: 5 · 2018: 15 · 2017: 19 · 2016: 9 · 2015: 6 · 2014: 1
- FWCI
- 6.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behaviour Research and Therapy (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- anxiety disorders, fear conditioning, fear generalization, fear extinction, endophenotypes, anxiety treatment
- MeSH terms
- Anxiety Disorders, Association Learning, Conditioning, Psychological, Extinction, Psychological, Fear, Humans, Neurosciences
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