The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Tractography-Activation Models Applied to Subcallosal Cingulate Deep Brain Stimulation
Open accessAbstract
Deep brain stimulation (DBS) of the subcallosal cingulate white matter (SCCWM) is an experimental therapy for major depressive disorder (MDD). The specific axonal pathways that mediate the anti-depressant effects of DBS remain unknown. Patient-specific tractography-activation models (TAMs) are a new tool to help identify pathways modulated by DBS. TAMs consist of four basic components: 1) anatomical and diffusion-weighted imaging data acquired on the patient; 2) probabilistic tractography from the brain region surrounding the implanted DBS electrode; 3) finite element models of the electric field generated by the patient-specific DBS parameter settings; and 4) application of the DBS electric field to multi-compartment cable models of axons, with trajectories defined by the tractography, to predict action potential generation in specific pathways. This study presents TAM predictions from DBS of the SCCWM in one MDD patient. Our findings suggest that small differences in electrode location can generate substantial differences in the directly activated pathways.
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“it is possible that the subcallosal cingulate stimulation affects pathways that connect with the OFC (Johansen-Berg et al., 2008; Lujan et al., 2013; Dunlop et al., 2017; Riva-Posse et al., 2018).”
From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Lujan et al., 2013
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Deep Brain Stimulation for Treatment-Resistant Depression
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Analysis of a Model for Excitation of Myelinated Nerve
McNeal, D. R. (1976) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.1976.324593 · Cited by 833
McIntyre, C. C., Richardson, A. G., & Grill, W. M. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00353.2001 · Cited by 764
Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Unipolar and Bipolar Depression
Holtzheimer, P. E. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1456 · Cited by 608
Self-citationJohansen-Berg, H., Gutman, D. A., Behrens, T. E. J., Matthews, P. M., Rushworth, M. F. S., Katz, E., Lozano, A. M., & Mayberg, H. S. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm167 · Cited by 561
Patient-specific analysis of the volume of tissue activated during deep brain stimulation
Butson, C. R., Cooper, S. E., Henderson, J. M., & McIntyre, C. C. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.09.034 · Cited by 490
Conductivity tensor mapping of the human brain using diffusion tensor MRI
Tuch, D. S., Wedeen, V. J., Dale, A. M., George, J., & Belliveau, J. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171473898 · Cited by 436
A tractography analysis of two deep brain stimulation white matter targets for depression
Gutman, D. A., Holtzheimer, P. E., Behrens, T. E. J., Johansen-Berg, H., & Mayberg, H. S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.021 · Cited by 220
Chaturvedi, A., Butson, C. R., Lempka, S. F., Cooper, S. E., & McIntyre, C. C. (2010) · Brain stimulation · doi:10.1016/j.brs.2010.01.003 · Cited by 215
Lehman, J. F., Greenberg, B. D., McIntyre, C. C., Rasmussen, S. A., & Haber, S. N. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0595-11.2011 · Cited by 194
Deep brain stimulation for treatment-resistant depression
Holtzheimer, P. E., & Hamani, C. (2014) · doi:10.2217/ebo.13.577 · Cited by 172
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The orbitofrontal cortex: reward, emotion and depression
Rolls, E. T., Cheng, W., & Feng, J. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa196 · Cited by 474
Riva-Posse, P., Choi, K. S., Holtzheimer, P. E., McIntyre, C. C., Gross, R. E., Chaturvedi, A., Crowell, A. L., Garlow, S. J., Rajendra, J. K., & Mayberg, H. S. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.03.029 · Cited by 460
Bergfeld, I. O., Mantione, M., Hoogendoorn, M. L. C., Ruhé, H. G., Notten, P., van Laarhoven, J., Visser, I., Figee, M., de Kwaasteniet, B. P., Horst, F., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0152 · Cited by 336
The orbitofrontal cortex and emotion in health and disease, including depression
Rolls, E. T. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.09.021 · Cited by 343
Dandekar, M. P., Fenoy, A. J., Carvalho, A. F., Soares, J. C., & Quevedo, J. (2018) · Molecular Psychiatry · doi:10.1038/mp.2018.2 · Cited by 265
Metadata
- Authors
- Lujan, J. L., Chaturvedi, A., Choi, K. S., Holtzheimer, P. E., Gross, R. E., Mayberg, H. S., & McIntyre, C. C.
- Affiliations
- Cleveland Clinic (US)
- Georgia Institute of Technology (US)
- Dartmouth College (US)
- Emory University (US)
- Corresponding author
- McIntyre, Cameron C.
- Venue
- Brain stimulation
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 6
- Issue
- 5
- Pages
- 737-739
- ISSN
- 1876-4754 (ISSN-L)
- 1935-861X
- PMC
- PMC3772993
- OpenAlex
- W2123940881
- Cited by
- 101
- References
- 13
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 11 · 2019: 4 · 2018: 10 · 2017: 10 · 2016: 11 · 2015: 13 · 2014: 9 · 2013: 2
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain stimulation (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R01 NS059736)
- Dana Foundation
- Stanley Foundation
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- deep brain stimulation, major depressive disorder, probabilistic tractography, action potential generation, electrode placement
- MeSH terms
- Brain Mapping, Major Depressive Disorder, Gyrus Cinguli, Humans, Models, Neurological, Finite Element Analysis, Deep Brain Stimulation, Diffusion Tensor Imaging
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