The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Incidence of systemic fungal infection and related mortality following severe burns
Abstract
Advancements in burn care therapy have extended survival of seriously burned patients, exposing burn patients to increased risk of infectious complications, notably fungal infections. We performed a 12-year review of autopsied patients with severe burns for the presence of fungal infection at the US Army Institute of Surgical Research Burn Center between February 1991 and November 2003. The primary goal was to identify the relationship between fungal element noted in autopsy and mortality, and to determine contributing factors that increase a patient's susceptibility to fungal infection. A total of 228 deaths (6.1%) resulted from the 3751 admissions of which 97 underwent autopsy. Fungal elements were identified on histopathology in 44% (43 of 97) of autopsied patients with an attributable mortality of 33% (14 of 43). Aspergillus and Candida were the most frequently recovered fungi, but Aspergillus was recovered in 13 of the 14 cases with fungus identified as an attributable cause of death. The most common sites of infections with attributable mortality were wounds (86%) and the pulmonary system (14%). Total body surface area (TBSA) burn and length of stay (survival after burn) were identified as contributing factors for the incidence of fungal element in autopsy on ROC curve analysis. More severely injured patients with greater %TBSA burn injury and full-thickness burns require a longer recovery period resulting in a longer hospital stay. The propensity for fungal infection i…
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“We identified direct evidence from three RCTs that compared procalcitonin-guided protocols for antibiotic initiation vs usual care (129-131).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [130]
In the citing paper
“A meta-analysis of the three trials (n = 1,769 ICU patients) found no difference in short-term mortality (RR, 0.99; 95% CI, 0.86 to 1.15), length of ICU stays (MD, 0.19 days; 95% CI, -0.98 to 1.36) or length of hospitalization (MD, 7.00 days; 95% CI, -26.24 to 12.24).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [130]
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Walsh, T. J., Anaissie, E. J., Denning, D. W., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Segal, B. H., Steinbach, W. J., Stevens, D. A., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/525258 · Cited by 2,705
Meta-analysis of early excision of burns
Ong, Y. S., Samuel, M., & Song, C. (2006) · Burns · doi:10.1016/j.burns.2005.09.005 · Cited by 430
Efficacy of topical silver against fungal burn wound pathogens
Wright, J. B., Lam, K., Hansen, D., & Burrell, R. E. (1999) · American Journal of Infection Control · doi:10.1016/s0196-6553(99)70055-6 · Cited by 384
Current Treatment Recommendations for Topical Burn Therapy
Monafo, W. W., & West, M. A. (1990) · Drugs · doi:10.2165/00003495-199040030-00004 · Cited by 181
Horvath, E. E., Murray, C. K., Vaughan, G. M., Chung, K. K., Hospenthal, D. R., Wade, C. E., Holcomb, J. B., Wolf, S. E., Mason, A. D., & Cancio, L. C. (2007) · Annals of Surgery · doi:10.1097/01.sla.0000256914.16754.80 · Cited by 151
Self-citationBecker, W. K. (1991) · Archives of Surgery · doi:10.1001/archsurg.1991.01410250048008 · Cited by 144
Positive Fungal Cultures in Burn Patients: A Multicenter Review
Ballard, J., Edelman, L. S., Saffle, J. R., Sheridan, R. L., Kagan, R. J., Bracco, D., Cancio, L. C., Cairns, B. A., Baker, R., Fillari, P., et al. (2008) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e31815f6ecb · Cited by 143
Self-citationGómez, R. S., Murray, C. K., Hospenthal, D. R., Cancio, L. C., Renz, E. M., Holcomb, J. B., Wade, C. E., & Wolf, S. E. (2009) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2008.11.012 · Cited by 137
Self-citationFungal infection in surgical patients
Dean, D. A., & Burchard, K. W. (1996) · The American Journal of Surgery · doi:10.1016/s0002-9610(97)89647-x · Cited by 131
Correlation of culture with histopathology in fungal burn wound colonization and infection
Schofield, C. M., Murray, C. K., Horvath, E. E., Cancio, L. C., Kim, S. H., Wolf, S. E., & Hospenthal, D. R. (2007) · Burns · doi:10.1016/j.burns.2006.08.040 · Cited by 108
Self-citationFungal Sepsis in Surgical Patients
Burchard, K. W. (1983) · Archives of Surgery · doi:10.1001/archsurg.1983.01390020065011 · Cited by 94
Ong, A. W., Cohn, S. M., Cohn, K. A., Jaramillo, D., Parbhu, R., McKenney, M. G., Barquist, E. S., & Bell, M. D. (2002) · Journal of the American College of Surgeons · doi:10.1016/s1072-7515(02)01123-7 · Cited by 69
The role of autopsy on patients with burns
Fish, J. S., Hartshorne, N. J., Reay, D. T., & Heimbach, D. M. (2000) · Journal of Burn Care & Rehabilitation · doi:10.1067/mbc.2000.108091 · Cited by 15
Incidence and mortality of systemic fungal infection in burned patients
Piette, A., Blot, S. I., Vandewoude, K., & Vogelaers, D. P. (2009) · Burns · doi:10.1016/j.burns.2008.12.015 · Cited by 2
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Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935
Ullmann, A. J., Aguado, J. M., Arikan-Akdagli, S., Denning, D. W., Groll, A. H., Lagrou, K., Lass-Flörl, C., Lewis, R. E., Munoz, P., Verweij, P. E., et al. (2018) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2018.01.002 · Cited by 1,556
Efflux-Mediated Antifungal Drug Resistance
Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., Tanabe, K., Niimi, M., Goffeau, A., & Monk, B. C. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00051-08 · Cited by 608
The leading causes of death after burn injury in a single pediatric burn center
Williams, F. N., Herndon, D. N., Hawkins, H. K., Lee, J. O., Cox, R. A., Kulp, G. A., Finnerty, C. C., Chinkes, D. L., & Jeschke, M. G. (2009) · Critical Care · doi:10.1186/cc8170 · Cited by 375
Metadata
- Authors
- Murray, C. K., Loo, F. L., Hospenthal, D. R., Cancio, L. C., Jones, J. A., Kim, S. H., Holcomb, J. B., Wade, C. E., & Wolf, S. E.
- Affiliations
- Brooke Army Medical Center (US)
- United States Army Institute of Surgical Research (US)
- ORCID
- Venue
- Burns
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 34
- Issue
- 8
- Pages
- 1108-1112
- ISSN
- 0305-4179 (ISSN-L)
- OpenAlex
- W2031890657
- Cited by
- 149
- References
- 14
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 9 · 2023: 7 · 2022: 6 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 3 · 2016: 14 · 2015: 9 · 2014: 10 · 2013: 6 · 2012: 7
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Burns (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Burn Injury Management and Outcomes
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
- Keywords
- systemic fungal infection, severe burns, burn mortality, autopsy findings, Aspergillus, Candida, wound infection, fungal lung infection, total body surface area burned, length of hospital stay, third-degree burns, antifungal therapy, burn wound closure
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aspergillus, Autopsy, Body Surface Area, Burns, Child, Child, Preschool, Female, Humans, Length of Stay, Lung Diseases, Fungal, Male, Middle Aged, Retrospective Studies, Risk Factors, Texas, Wound Infection, Incidence, Young Adult
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