Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress

Zhang, Lei; Fok, Jacqueline J.L.; Mirabella, Fabio; Aronson, Lauren I.; Fryer, Rosemary A.; Workman, Paul; Morgan, Gareth J.; Davies, Faith E.

doi:10.1016/j.canlet.2013.07.023

Hsp70 inhibition induces myeloma cell death via the intracellular accumulation of immunoglobulin and the generation of proteotoxic stress

Multiple myeloma (MM) cells rely on protein homeostatic mechanisms for survival. These mechanisms could be therapeutically targeted via modulation of the heat shock response. We studied the roles of Hsp72 and Hsc70, and show that the two major cytoplasmic Hsp70s play a key role in regulating prot…