A positive feedback loop of IL-17B-IL-17RB activates ERK/β-catenin to promote lung cancer metastasis

Yang, Yi-Fang; Lee, Yi-Chen; Lo, Steven; Chung, Yi-Ning; Hsieh, Ya-Ching; Chiu, Wen-Chin; Yuan, Shyng-Shiou F.

doi:10.1016/j.canlet.2018.02.037

A positive feedback loop of IL-17B-IL-17RB activates ERK/β-catenin to promote lung cancer metastasis

Inflammation contributes to the development and progression of cancer. Interleukin-17 (IL-17) is an inflammatory cytokine that functions in inflammation and cancer, as well as several other cellular processes. In this study, we investigated the roles and the prognostic value of IL-17 and the IL-1…