The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Triple-negative breast cancer therapeutic resistance: Where is the Achilles' heel?
Abstract
Triple-negative breast cancer (TNBC) shows a higher response rate to systemic therapy compared with other breast cancer subtypes. However, the tumor differentiation of TNBC is poorer, with an early tendency to metastasis and a higher recurrence rate. Relapsed and metastatic TNBCs usually progress more rapidly, showing strong resistance to chemotherapy and radiotherapy. Due to the lack of combinatorial targeted drugs, alternative treatments fail to improve these patient's prognosis and the quality of life. Finding the Achilles' heel of TNBC is critical for patients with advanced TNBC. Here, we summarize the latest advances in the mechanisms underlying TNBC therapeutic resistance, consider how these mechanisms may affect the development and utilization of TNBC targeted drugs, and discuss the rationale of relevant signals as therapeutic targets. Also, we review the clinical trials registered in ClinicalTrial.gov for TNBC patients, which comprehensively reveals current research and development of novel TNBC targeted drugs and future trends.
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1 retracted
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RetractedThe Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
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Tumor mutational load predicts survival after immunotherapy across multiple cancer types
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Cited by
Chen, Q., Zhang, M., Huang, H., Dong, C., Dai, X., Feng, G., Lin, L., Sun, D., Yang, D., Xie, L., et al. (2023) · Advanced Science · doi:10.1002/advs.202206244 · Cited by 83
Si, Y., Yue, J., Liu, Z., Li, M., Du, F., Wang, X., Dai, Z., Hu, N., Ju, J., Gao, S., et al. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s297933 · Cited by 52
Zhang, H., Zhu, S., Zhou, H., Li, R., Xia, X., & Xiong, H. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1098357 · Cited by 46
Liu, R., Wang, R., Zhao, M., Liu, Y., Zhu, X., Wu, X., Du, S., Gu, Z., & Du, J. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101997 · Cited by 23
Yue, L., Geng, F., Jin, J., Li, W., Liu, B., Du, M., Gao, X., Lü, J., & Pan, X. (2024) · Biotechnology Journal · doi:10.1002/biot.202400428 · Cited by 14
Metadata
- Authors
- Bai, X., Ni, J., Beretov, J., Graham, P., & Li, Y.
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 497
- Pages
- 100-111
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W3092655545
- Cited by
- 283
- References
- 89
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- closed
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