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Thermal Analysis of Chitosan Based Networks
Abstract
In this work two kinds of material were studied: chitosan cross-linked with glutaraldehyde and in a blend with PEO. The resulting products as well as chitosan and PEO raw materials, were analyzed by TG/DTG, DSC and DMTA to determinate the in?uence of cross-linking and PEO addition on thermal properties of the resulting materials. It was observed by thermogravimetry that the water-polymer interaction will be different for the cross-linked material compared to the blend, according to the specific site availability. The in?uence of such modifications (cross-linking and PEO addition), on chitosan thermal stability was also studied. The DSC results showed a good agreement with the TG/DTG results, reinforcing the interpretation given for TG/DTG results. DMTA results indicate that glass transition temperature is around 50 degrees C for the polymer under study.
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“Although CS has numerous valuable advantages, it also has several limitations that affect its use in the delivery of anticancer drugs. These include low thermal stability [11,12] and ductility [13,14], poor solubility of CS above pH 6.5 [15,16], high hydrophilicity and swelling properties, which may lead to premature drug release and reduced structural stability.”
From Chitosan-Based Drug Delivery Systems for Targeted Chemotherapy in Colorectal Cancer: A Scoping Review (2025) · cites this paper as [11]
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Research works printed but not linked: 26
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Biodegradable polymer blends based on corn starch and thermoplastic chitosan processed by extrusion
Mendes, J. F., Paschoalin, R. T., Carmona, V. B., Sena Neto, A. R., Marques, A. C. P., Marconcini, J. M., Mattoso, L. H. C., Medeiros, E. S., & Oliveira, J. E. (2016) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2015.10.093 · Cited by 416
Piotrowska, U., Szatko, J., Nowakowska, A., Klimaszewska, E., Ogorzałek, M., & Sobczak, M. (2025) · Marine Drugs · doi:10.3390/md23120467 · Cited by 14
Metadata
- Authors
- Neto, C. G. T., Giacometti, J. A., Job, A. E., Ferreira, F. C., Fonseca, J. L. C., & Pereira, M. R.
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2005-11
- Volume
- 62
- Issue
- 2
- Pages
- 97-103
- ISSN
- 0144-8617
- Cited by
- 508
- References
- 0
- Language
- en
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