The DOI matches its Crossref record.
Water-solubility of chitosan and its antimicrobial activity
Abstract
Chitosan samples with different molecular weights were prepared by depolymerization with hemicellusase, and water-soluble half N-acetylated chitosan samples were obtained by N-acetylation with acetic anhydride. The action of chitosans with molecular weights Mw from 1.4x10³ to 4.0x10⁵ on the growth of Staphylococcus aureus, Escherichia coli and Candida albicans was explored by microcalorimetry. The water-soluble half N-acetylated chitosans and chitooligomers had no significant antimicrobial activity. Moreover, water-soluble chitosans and chitooligomers promoted the growth of C. albicans. In contrast, water-insoluble chitosan in acidic medium exhibited inhibitory effect against these microorganisms. The water-insoluble chitosans with Mw around 5x10⁴ were the optimum for antimicrobial action in these tested samples. The antimicrobial mechanism of dissolved water-insoluble chitosan was hypothesized as forming an impervious layer around the cell. The results suggest that optimum chitosan as food preservative should be water-insoluble chitosan from mild depolymerization of native chitosan.
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“Nevertheless, pure chitosan’s utility and applications are limited due to its insolubility in water and also most organic solvents.159”
From Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment (2022) · cites this paper as [159]
In the citing paper
“Although CS has numerous valuable advantages, it also has several limitations that affect its use in the delivery of anticancer drugs. These include low thermal stability [11,12] and ductility [13,14], poor solubility of CS above pH 6.5 [15,16], high hydrophilicity and swelling properties, which may lead to premature drug release and reduced structural stability.”
From Chitosan-Based Drug Delivery Systems for Targeted Chemotherapy in Colorectal Cancer: A Scoping Review (2025) · cites this paper as [15]
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Chan, S. S., Khoo, K. S., Chew, K. W., Ling, T. C., & Show, P. L. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2021.126159 · Cited by 422
Current Advances in Chitosan Nanoparticles Based Oral Drug Delivery for Colorectal Cancer Treatment
Choukaife, H., Seyam, S., Alallam, B., Doolaanea, A. A., & Alfatama, M. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s375229 · Cited by 127
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Metadata
- Authors
- QIN, C., LI, H., XIAO, Q., LIU, Y., ZHU, J., & DU, Y.
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2006-03-03
- Volume
- 63
- Issue
- 3
- Pages
- 367-374
- ISSN
- 0144-8617
- Cited by
- 636
- References
- 0
- Language
- en
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