Hydroxyapatite-hybridized chitosan/chitin whisker bionanocomposite fibers for bone tissue engineering applications
Abstract
Biomimetic nanofibrous scaffolds derived from natural biopolymers for bone tissue engineering applications require good mechanical and biological performances including biomineralization. The present work proposes the utility of chitin whisker (CTWK) to enhance mechanical properties of chitosan/poly(vinyl alcohol) (CS/PVA) nanofibers and to offer osteoblast cell growth with hydroxyapatite (HA) mineralization. By using diacid as a solvent, electrospun CS/PVA nanofibrous membranes containing CTWK can be easily obtained. The dimension stability of nanofibrous CS/PVA/CTWK bionanocomposite is further controlled by exposing to glutaraldehyde vapor. The nanofibrous membranes obtained allow mineralization of HA in concentrated simulated body fluid resulting in an improvement of Young's modulus and tensile strength. The CTWK combined with HA in bionanocomposite is a key to promote osteoblast cell adhesion and proliferation. The present work, for the first time, demonstrates the use of CTWKs for bionanocomposite fibers of chitosan and its hydroxyapatite biomineralization with the function in osteoblast cell culture. These hydroxyapatite-hybridized CS/PVA/CTWK bionanocomposite fibers (CS/PVA/CTWK-HA) offer a great potential for bone tissue engineering applications.
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Hydrogels made from natural polymers, such as polysaccharides (sodium alginate, gelatin, chitosan, hyaluronic acid, and proteins), exhibit good biocompatibility and bioresorbability.
“Additionally, hydrogels made from natural polymers, such as polysaccharides (sodium alginate, gelatin, chitosan, hyaluronic acid, and proteins), exhibit good biocompatibility and bioresorbability [115,116].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [115]
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
Discher, D. E., Janmey, P., & Wang, Y.-L. (2005) · Science · doi:10.1126/science.1116995 · Cited by 6,382 · see citing works
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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
Vach Agocsova, S., Culenova, M., Birova, I., Omanikova, L., Moncmanova, B., Danisovic, L., Ziaran, S., Bakos, D., & Alexy, P. (2023) · Materials · doi:10.3390/ma16124267 · Cited by 98 · see citing works
- Authors
- Pangon, A., Saesoo, S., Saengkrit, N., Ruktanonchai, U., & Intasanta, V.
- Affiliations
- National Science and Technology Development Agency (TH)
- Corresponding author
- Pangon, Autchara
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 144
- Pages
- 419-427
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2288364049
- Cited by
- 112
- References
- 1
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 11 · 2023: 12 · 2022: 6 · 2021: 13 · 2020: 13 · 2019: 13 · 2018: 17 · 2017: 13 · 2016: 2
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institute for the Promotion of Teaching Science and Technology (29/2557)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Nanocomposite Films for Food Packaging
- Keywords
- chitin whiskers, chitosan, polyvinyl alcohol, hydroxyapatite, electrospinning, biomineralization, bone tissue engineering, osteoblast adhesion, glutaraldehyde crosslinking, simulated body fluid, mechanical properties, nanofibrous membranes
- MeSH terms
- Animals, Biocompatible Materials, Bone and Bones, Cell Survival, Chitin, Osteoblasts, Polyvinyl Alcohol, 3T3 Cells, Durapatite, Tissue Engineering, Chitosan, Cell Proliferation, Mice, Nanocomposites, Mechanical Phenomena, Nanofibers
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