Dextran hydrogels incorporated with bioactive glass-ceramic: Nanocomposite scaffolds for bone tissue engineering
Open accessAbstract
A series of nanocomposite scaffolds comprised of dextran (Dex) and sol-gel derived bioactive glass ceramic nanoparticles (nBGC: 0-16 (wt%)) were fabricated as bioactive scaffolds for bone tissue engineering. Scanning electron microscopy showed Dex/nBGC scaffolds were consisting of a porous 3D microstructure with an average pore size of 240 μm. Energy-dispersive x-ray spectroscopy illustrated nBGC nanoparticles were homogenously distributed within the Dex matrix at low nBGC content (2 wt%), while agglomeration was observed at higher nBGC contents. It was found that the osmotic pressure and nBGC agglomeration at higher nBGC contents leads to increased water uptake, then reduction of the compressive modulus. Bioactivity of Dex/nBGC scaffolds was validated through apatite formation after submersion in the simulated body fluid. Dex/nBGC composite scaffolds were found to show improved human osteoblasts (HOBs) proliferation and alkaline phosphatase (ALP) activity with increasing nBGC content up to 16 (wt%) over two weeks. Owing to favorable physicochemical and bioactivity properties, the Dex/nBGC composite hydrogels can be offered as promising bioactive scaffolds for bone tissue engineering applications.
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The bioactivity of dextran hydrogel networks can be improved by incorporating bioceramics into the matrix.
“The bioactivity of dextran hydrogel networks can be improved by incorporating bioceramics into the matrix [72].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [72]
These scaffolds exhibited enhanced reactivity with body fluids, creating active sites for mineralization.
“Furthermore, these scaffolds exhibited enhanced reactivity with body fluids, creating active sites for mineralization [72].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [72]
Nikpour et al. demonstrated that the inclusion of bioactive glass nanoparticles within the hydrogel matrix resulted in a significant improvement in mechanical strength.
“They demonstrated that the inclusion of bioactive glass nanoparticles within the hydrogel matrix resulted in a significant improvement in mechanical strength.”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [72]
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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
Vach Agocsova, S., Culenova, M., Birova, I., Omanikova, L., Moncmanova, B., Danisovic, L., Ziaran, S., Bakos, D., & Alexy, P. (2023) · Materials · doi:10.3390/ma16124267 · Cited by 98 · see citing works
- Authors
- Nikpour, P., Salimi-Kenari, H., Fahimipour, F., Rabiee, S. M., Imani, M., Dashtimoghadam, E., & Tayebi, L.
- Affiliations
- University of Mazandaran (IR)
- Marquette University (US)
- Babol Noshirvani University of Technology (IR)
- Iran Polymer and Petrochemical Institute (IR)
- Corresponding author
- Rabiee, Sayed Mahmood
- ORCID
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 190
- Pages
- 281-294
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2790590204
- Cited by
- 97
- References
- 0
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 11 · 2023: 19 · 2022: 12 · 2021: 17 · 2020: 10 · 2019: 7 · 2018: 3
- FWCI
- 3.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Carbohydrate Polymers (acceptedVersion)
- PubMed (publishedVersion)
- e-Publications@Marquette (Marquette University) (submittedVersion)
- Funders
- Iran National Science Foundation (93043263)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- dextran hydrogels, nanocomposite scaffolds, bone tissue engineering, nanoparticle agglomeration, water absorption, compressive modulus, apatite formation, simulated body fluid, human osteoblasts, alkaline phosphatase activity, osteoblast proliferation
- MeSH terms
- Alkaline Phosphatase, Biocompatible Materials, Bone and Bones, Calcification, Physiologic, Cell Adhesion, Cell Survival, Ceramics, Dextrans, Temperature, Hydrogels, Tissue Engineering, Cell Proliferation, Nanocomposites, Tissue Scaffolds, Mechanical Phenomena
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