Cited by 113Advanced Drug Delivery SystemsDrug Solubulity and Delivery SystemsNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Multifunctional quercetin conjugated chitosan nano-micelles with P-gp inhibition and permeation enhancement of anticancer drug

Abstract

In this study, quercetin-chitosan conjugate (QT-CS) was synthesized for oral delivery of doxorubicin (DOX) to improve its oral bioavailability by increasing its water solubility, opening tight junction and bypassing the P-glycoprotein (P-gp). The prepared QT-CS self-assembled into micelles which could encapsulate DOX with high encapsulation rate, small particle size (136.9 nm) and strong zeta potential (+16.2 mV). QT-CS-DOX micelles displayed sustained-release profile in gastrointestinal simulation fluid (pH 1.2/pH 7.4). QT-CS micelles could promote cellular uptake of doxorubicin, which was 2.2 folds higher than that of free doxorubicin. The trans epithelial electrical resistance (TEER) value of Caco-2 monolayer cells was significantly reduced (about 57%) by drug loaded QT-CS micelles, leading to a high apparent permeability coefficient (P app) of doxorubicin, which was 10.17 folds higher than that of free doxorubicin. Above results indicate that QT-CS micelles are promising vehicles for the oral delivery of insoluble anticancer drugs.

Overview

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Crossref · 10.1016/j.carbpol.2018.09.020

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31 of 31 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Mu, Y., Fu, Y., Li, J., Yu, X., Li, Y., Wang, Y., Wu, X., Zhang, K., Kong, M., Feng, C., & Chen, X.
Affiliations
  • Ocean University of China (CN)
  • Chinese PLA General Hospital (CN)
Corresponding author
  • Feng, Chao
  • Chen, Xiguang
Venue
Carbohydrate Polymers
Publisher
Elsevier BV
Published
2019-01
Volume
203
Pages
10-18
ISSN
0144-8617 (ISSN-L)
OpenAlex
W2890083641
Cited by
113
References
31
Citations by year
2026: 6 · 2025: 10 · 2024: 11 · 2023: 18 · 2022: 20 · 2021: 18 · 2020: 18 · 2019: 11
FWCI
5.51
Type
journal article
Language
en
Open access
closed
Locations
  • Carbohydrate Polymers (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (U1706212, 81671828)
  • Applied Basic Research Plan of Qingdao (16-5-1-70-jch)
  • Taishan Scholar Program
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
doxorubicin, oral drug delivery, P-glycoprotein inhibition, self-assembly, sustained drug release, Caco-2 cell monolayers, transepithelial electrical resistance, cellular uptake, anticancer drug delivery, poorly water-soluble drugs
MeSH terms
Administration, Oral, Antineoplastic Agents, Doxorubicin, Drug Carriers, Humans, Micelles, Particle Size, Quercetin, ATP Binding Cassette Transporter, Subfamily B, Caco-2 Cells, Tight Junctions, Chitosan, Nanostructures, Static Electricity, Drug Liberation

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