Co-delivery of doxorubicin and curcumin by a pH-sensitive, injectable, and in situ hydrogel composed of chitosan, graphene, and cellulose nanowhisker
Abstract
Hydrogels are promising carriers for the controlled drug delivery in response to the external stimuli such as pH and temperature. Here, a new hydrogel is designed and synthesized from the cross-linking of graphene, chitosan, and cellulose nanowhisker via Schiff base reaction by a synthetic dialdehyde. The hydrogel presented a flexible structure and responded to altering pH and adding the external stimuli such as benzaldehyde and amino acid cysteine. The synthesized hydrogel was stable under physiological conditions. In vivo test showed that the hydrogel is subcutaneously injectable. Three drug-loaded hydrogels were synthesized, and in vitro drug release study showed a pH-dependent release of drugs in PBS solution.
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The CGW hydrogel exhibits potential as a viable option for localized drug delivery systems.
“The findings of this study indicate that the CGW hydrogel exhibits potential as a viable option for localized drug delivery systems (Omidi et al., 2020).”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Omidi et al., 2020
The CGW hydrogel formulation exhibited a pH-responsive release pattern for anticancer drugs.
“The hydrogel formulation exhibited a pH-responsive release pattern in relation to the delivery of anticancer drugs.”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Omidi et al., 2020
In vivo experiment demonstrated rapid gelation of the CGW hydrogel upon subcutaneous injections into rat skin.
“The in vivo experiment demonstrated rapid gelation of the hydrogel upon subcutaneous injections into the skin of rats.”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Omidi et al., 2020
Antimicrobial investigations confirmed that CGW exhibits robust antibacterial activity specifically against Gram-positive bacteria.
“The antimicrobial investigations conducted have confirmed that CGW exhibits robust antibacterial activity specifically against Gram-positive bacteria.”
From pH stimuli-responsive hydrogels from non-cellulosic biopolymers for drug delivery. (2023) · cites this paper as Omidi et al., 2020
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References 23 · Cited by 118
- Authors
- Omidi, S., Pirhayati, M., & Kakanejadifard, A.
- Affiliations
- Lorestan University (IR)
- Malayer University (IR)
- Corresponding author
- Omidi, Sakineh
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 231
- Pages
- 115745
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W2995996910
- Cited by
- 118
- References
- 23
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 11 · 2023: 20 · 2022: 19 · 2021: 34 · 2020: 10
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Carbohydrate Polymers (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Lorestan University of Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- doxorubicin, curcumin, co-delivery, pH-responsive hydrogels, injectable hydrogel, in situ forming hydrogels, chitosan, graphene, Schiff base crosslinking, controlled drug release, anticancer drug delivery
- MeSH terms
- Benzaldehydes, Cellulose, Curcumin, Cysteine, Doxorubicin, Graphite, Humans, Hydrogen-Ion Concentration, Temperature, Drug Delivery Systems, Hydrogels, Chitosan, Nanostructures, Drug Liberation
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