The DOI matches its Crossref record; 150 of the 150 references it cites were found in a registry or an index.
Chitosan: A review of molecular structure, bioactivities and interactions with the human body and micro-organisms
Abstract
Chitosan has many desirable attributes e.g. antimicrobial properties and promoting wound healing, and is used in various applications. This article first discusses how degree of deacetylation (DD) and molecular weight (MW) impacts on what level of bioactivities chitosan manifests, then introduces the "molecular chain configuration" model to explain various possible mechanisms of antimicrobial interactions between chitosan with different MW and different types of bacteria. Similarly, the possible pathways of how chitosan reacts with cancer and the body's immune system to demonstrate immune and antitumor effects are also discussed by using this model. Moreover, the possible mechanisms of how chitosan enhances coagulation and wound healing are also discussed. With these beneficial bioactivities in mind, the application of chitosan in surgery, tissue engineering and oncology is outlined. This review concludes that as chitosan demonstrates many beneficial bioactivities via multiple mechanisms, it is an important polymer with a promising future in medicine.
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1 retracted
Abd El-Hack, M. E., El-Saadony, M. T., Shafi, M. E., Zabermawi, N. M., Arif, M., Batiha, G. E., Khafaga, A. F., Abd El-Hakim, Y. M., & Al-Sagheer, A. A. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.08.153 · Cited by 782
RetractedChitosan as antimicrobial agent: applications and mode of action.
Rabea, E. I., Badawy, M. E.-T., Stevens, C. V., Smagghe, G., & Steurbaut, W. (2003) · Biomacromolecules · doi:10.1021/bm034130m · Cited by 3,123
Chitosan—A versatile semi-synthetic polymer in biomedical applications
Dash, M., Chiellini, F., Ottenbrite, R. M., & Chiellini, E. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.02.001 · Cited by 2,903
Chitin and chitosan polymers: Chemistry, solubility and fiber formation
Pillai, C. K. S., Paul, W., & Sharma, C. P. (2009) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2009.04.001 · Cited by 2,745
Chitin and Chitosan Preparation from Marine Sources. Structure, Properties and Applications
Younes, I., & Rinaudo, M. (2015) · Marine Drugs · doi:10.3390/md13031133 · Cited by 2,562
Berger, J., Reist, M., Mayer, J. M., Felt, O., Peppas, N. A., & Gurny, R. (2004) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(03)00161-9 · Cited by 2,163
Chitosan-based biomaterials for tissue engineering
Croisier, F., & Jérôme, C. (2013) · European Polymer Journal · doi:10.1016/j.eurpolymj.2012.12.009 · Cited by 2,149
Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review
Francis Suh, J.-K., & Matthew, H. W. T. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00126-5 · Cited by 1,997
Food applications of chitin and chitosans
Shahidi, F., Arachchi, J. K. V., & Jeon, Y.-J. (1999) · Trends in Food Science & Technology · doi:10.1016/s0924-2244(99)00017-5 · Cited by 1,826
Biopolymer-Based Hydrogels As Scaffolds for Tissue Engineering Applications: A Review
Van Vlierberghe, S., Dubruel, P., & Schacht, E. (2011) · Biomacromolecules · doi:10.1021/bm200083n · Cited by 1,716
Cited by
El-Araby, A., Janati, W., Ullah, R., Ercisli, S., & Errachidi, F. (2024) · Frontiers in Chemistry · doi:10.3389/fchem.2023.1327426 · Cited by 280
Metadata
- Authors
- Kou, S. (., Peters, L., & Mucalo, M.
- Venue
- Carbohydrate Polymers
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 282
- Pages
- 119132
- ISSN
- 0144-8617 (ISSN-L)
- OpenAlex
- W4206088233
- Cited by
- 380
- References
- 150
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kou, S. (., Peters, L., & Mucalo, M. (2022). Chitosan: A review of molecular structure, bioactivities and interactions with the human body and micro-organisms. Carbohydrate Polymers. https://doi.org/10.1016/j.carbpol.2022.119132
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
