Malnutrition and Sarcopenia as Reasons for Caution with GLP-1 Receptor Agonist Use in HFpEF
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GI side effects of GLP-1 RAs may further compromise nutrient and fluid intake and/or absorption, exacerbating malnutrition.
“GI side effects (e.g., nausea, vomiting, constipation, and diarrhea) may further compromise nutrient and fluid intake and/or absorption, exacerbating malnutrition [58,59,60,61].”
From Nutrition and Physical Activity in Optimizing Weight Loss and Lean Mass Preservation in the Incretin-Based Medications Era: A Narrative Review (2025) · cites this paper as [58]
GLP-1 RAs act by slowing gastric emptying and modulating hunger centers, leading to progressive weight loss (especially lean mass, ranging from 20% to 50%) and increasing the risk of malnutrition.
“GLP-1 RAs act by slowing gastric emptying and modulating hunger centers, leading to progressive weight loss (especially lean mass, ranging from 20% to 50%) and increasing the risk of malnutrition [58,59,60,61].”
From Nutrition and Physical Activity in Optimizing Weight Loss and Lean Mass Preservation in the Incretin-Based Medications Era: A Narrative Review (2025) · cites this paper as [58]
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Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity
Kosiborod, M. N., Abildstrøm, S. Z., Borlaug, B. A., Butler, J., Rasmussen, S., Davies, M., Hovingh, G. K., Kitzman, D. W., Lindegaard, M. L., Møller, D. V., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2306963 · Cited by 1,669 · see citing works
Sargeant, J. A., Henson, J., King, J. A., Yates, T., Khunti, K., & Davies, M. J. (2019) · Endocrinology and Metabolism · doi:10.3803/enm.2019.34.3.247 · Cited by 231 · see citing works
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Cited by
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Glucagon-like peptide-1 receptor agonists and muscle mass effects
Ceasovschih, A., Asaftei, A., Lupo, M. G., Kotlyarov, S., Bartušková, H., Balta, A., Sorodoc, V., Sorodoc, L., & Banach, M. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107927 · Cited by 64 · see citing works
Scheen, A. J. (2025) · Diabetes & Metabolism · doi:10.1016/j.diabet.2025.101681 · Cited by 30 · see citing works
Vest, A. R., DiDomenico, R. J., Lichtenstein, L., Slater, T., Ekpo, E., Damluji, A. A., Bohula, E., Alviar, C. L., on behalf of the American Heart Association Acute Cardiac Care and General Cardiology Committee of the Council on Clinical Cardiology, & Council on Cardiovascular and Stroke Nursing (2026) · Circulation · doi:10.1161/cir.0000000000001405 · Cited by 15 · see citing works
Barana, L., De Fano, M., Cavallo, M., Manco, M., Prete, D., Fanelli, C. G., Porcellati, F., & Pippi, R. (2025) · Nutrients · doi:10.3390/nu18010131 · Cited by 13 · see citing works
- Authors
- DRIGGIN, E., & GOYAL, P.
- Affiliations
- Columbia University (US)
- Weill Cornell Medicine (US)
- Corresponding author
- GOYAL, PARAG
- Venue
- Journal of Cardiac Failure
- Publisher
- Elsevier BV
- Published
- 2024-04
- Volume
- 30
- Issue
- 4
- Pages
- 610-612
- ISSN
- 1071-9164 (ISSN-L)
- PMC
- PMC12217443
- OpenAlex
- W4391430089
- Cited by
- 24
- References
- 2
- Citations by year
- 2026: 2 · 2025: 20 · 2024: 2
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Journal of Cardiac Failure (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (K76AG064428, R24AG064025)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- GLP-1 receptor agonists, heart failure with preserved ejection fraction, malnutrition, sarcopenia, obesity, incretins, insulin secretion, glucagon secretion, hepatic glucose production, glycemic control, diabetes mellitus
- MeSH terms
- Glucagon-Like Peptide-1 Receptor Agonists, Heart Failure, Humans, Obesity, Stroke Volume, Malnutrition, Sarcopenia
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