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Cited by 355

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

The first minutes of reperfusion: a window of opportunity for cardioprotection

Piper, H·2004·Cardiovascular Research
DOI 10.1016/j.cardiores.2003.12.012
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Abstract

During the past decade, the understanding has grown that control of the conditions of reperfusion is critical for salvaging ischemic-reperfused myocardium. The first few minutes of reperfusion constitute a critical phase, as here lethal tissue injury in addition to that already developed during ischemia may be initiated. The identification of the mechanisms of reperfusion-induced cell death opens a new window of opportunity for cardioprotection in the clinic. Development of cardiomyocyte hypercontracture is a predominant feature of reperfusion injury. We and others have shown that control of hypercontracture in reperfusion reduces the extent of tissue injury. On the cellular level, it was shown that reperfusion-induced hypercontracture might either originate from a rigor-type mechanism, when energy recovery proceeds very slowly, or from Ca2+ overload, when energy recovery is rapid but cytosolic Ca2+ load is high. These two mechanisms can be influenced by various interventions that either connect with cytosolic Ca2+ control or myofibrillar Ca2+ sensitivity or with mitochondrial energy production. These experimental approaches will hopefully lead to novel strategies for clinical cardioprotection during the early phase of reperfusion.

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Metadata

Authors
Piper, H.
Venue
Cardiovascular Research
Publisher
Oxford University Press (OUP)
Published
2004-02-15
Volume
61
Issue
3
Pages
365-371
ISSN
0008-6363 (ISSN-L)
DOI
10.1016/j.cardiores.2003.12.012
OpenAlex
W2111912915
Cited by
355
References
12
FWCI
17.54
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: The first minutes of reperfusion: a window of opportunity for cardioprotection. https://app.cochat.ai/papers/10.1016/j.cardiores.2003.12.012
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Piper, H. (2004). The first minutes of reperfusion: a window of opportunity for cardioprotection. Cardiovascular Research. https://doi.org/10.1016/j.cardiores.2003.12.012

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.