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Molecular mechanisms of fluoride toxicity

Barbier, Olivier, Arreola-Mendoza, Laura, Del Razo, Luz María·2010·Chemico-Biological Interactions
DOI 10.1016/j.cbi.2010.07.011
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Abstract

Halfway through the twentieth century, fluoride piqued the interest of toxicologists due to its deleterious effects at high concentrations in human populations suffering from fluorosis and in in vivo experimental models. Until the 1990s, the toxicity of fluoride was largely ignored due to its "good reputation" for preventing caries via topical application and in dental toothpastes. However, in the last decade, interest in its undesirable effects has resurfaced due to the awareness that this element interacts with cellular systems even at low doses. In recent years, several investigations demonstrated that fluoride can induce oxidative stress and modulate intracellular redox homeostasis, lipid peroxidation and protein carbonyl content, as well as alter gene expression and cause apoptosis. Genes modulated by fluoride include those related to the stress response, metabolic enzymes, the cell cycle, cell-cell communications and signal transduction. The primary purpose of this review is to examine recent findings from our group and others that focus on the molecular mechanisms of the action of inorganic fluoride in several cellular processes with respect to potential physiological and toxicological implications. This review presents an overview of the current research on the molecular aspects of fluoride exposure with emphasis on biological targets and their possible mechanisms of involvement in fluoride cytotoxicity. The goal of this review is to enhance understanding of the mecha…

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Metadata

Authors
Barbier, O., Arreola-Mendoza, L., & Del Razo, L. M.
Venue
Chemico-Biological Interactions
Publisher
Elsevier BV
Published
2010-11
Volume
188
Issue
2
Pages
319-333
ISSN
0009-2797
DOI
10.1016/j.cbi.2010.07.011
Cited by
878
References
1
Language
en
Licence
Funders
Mexican Council for Science and Technology (56785, 104316)

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